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. 2024 Nov;103(11):4701-4705.
doi: 10.1007/s00277-024-05979-3. Epub 2024 Sep 3.

Early autologous and/or allogeneic stem cell transplantation for adult patients with advanced stage T- lymphoblastic leukemia/lymphoma or Burkitt lymphoma. A retrospective single-centre analysis

N Steiner  1 , K Baier  2 , D Ritter  2 , J Rudzki  2 , G Hetzenauer  2 , S Köck  2 , B Kircher  2 , E Gunsilius  2 , D Wolf  2 , D Nachbaur  2
Affiliations

Early autologous and/or allogeneic stem cell transplantation for adult patients with advanced stage T- lymphoblastic leukemia/lymphoma or Burkitt lymphoma. A retrospective single-centre analysis

N Steiner et al. Ann Hematol. 2024 Nov.

Abstract

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) and Burkitt lymphoma (BL) are uncommon, highly aggressive diseases originating either from immature precursor T cells or from mature B cells in BL. We retrospectively analyzed the outcome of an early autologous and/or allogeneic stem cell transplantation (SCT) concept in 28 patients with advanced stage T-ALL/LBL and BL after three to four remission induction/consolidation chemotherapy cycles. Considering only patients in first complete remission (CR), the 5-year overall survival (OS) and event-free survival (EFS) was 91% in patients with BL and 73% in patients with T-ALL/LBL with a 5-year relapse incidence (RI) of 9% in patients with BL and 27% in patients with T-ALL/LBL. All relapsing patients finally succumbed to the disease (n = 10) or complications/toxicity after having received a salvage allogeneic transplant (n = 5). Despite the low patient number our retrospective single-centre analysis by incorporating an early intensive high-dose chemo-/radiotherapy strategy with either autologous or allogeneic stem cell transplantation, although preliminary, show promising long-term outcome. Further studies are highly warranted to better define those patients who might benefit most from such a treatment approach.

Keywords: ASCT; AlloSCT; BL; T-ALL/LBL.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Overall survival of stem cell transplant patients with T-ALL/LBL and BL in CR1
Fig. 2
Fig. 2
Event-free survival of stem cell transplant patients with T-ALL/LBL and BL in CR1
Fig. 3
Fig. 3
Cumulative incidence of relapse of stem cell transplant patients with T-ALL/LBL and BL in CR1
See this image and copyright information in PMC

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