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Review
. 2025 Feb;398(2):1081-1097.
doi: 10.1007/s00210-024-03397-w. Epub 2024 Sep 3.

Can infliximab serve as a new therapy for neuropsychiatric symptoms?

Fatemeh Rahmati-Dehkordi  1   2   3 , Nafiseh Birang  4 , Mohammad Naser Jalalian  5 , Zeinab Tamtaji  6 , Ehsan Dadgostar  7   8 , Michael Aschner  9 , Mehdi Shafiee Ardestani  10 , Hamed Jafarpour  11 , Hamed Mirzaei  12 , Fatemeh Nabavizadeh  13   14 , Omid Reza Tamtaji  15   16
Affiliations
Review

Can infliximab serve as a new therapy for neuropsychiatric symptoms?

Fatemeh Rahmati-Dehkordi et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb.

Abstract

Neuropsychiatric disorders present a global challenge to public health. Mechanisms associated with neuropsychiatric disorders etiology include apoptosis, oxidative stress, and neuroinflammation. Tumor necrosis factor alpha, an inflammatory cytokine, mediates pathophysiology of neuropsychiatric disorders. Therefore, its inhibition by infliximab might afford a valuable target for intervention. Infliximab is commonly used to treat inflammatory diseases, including ulcerative colitis, Crohn's disease, and rheumatoid arthritis. Recently, it has been shown that infliximab improves cognitive dysfunction, depression, anxiety, and life quality. Here, we review contemporary knowledge supporting the need to further characterize infliximab as a potential treatment for neuropsychiatric disorders.

Keywords: Cognition; Depression; Inflammation; Infliximab; Neuropsychiatric disorders.

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Conflict of interest statement

Declarations. Ethics approval: This is a review study. The TUMS Research Ethics Committee has confirmed that no ethical approval is required. Consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

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