How to conduct clinical research in cardiovascular imaging: a primer for clinical cardiologists and researchers-a statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC

Denisa Muraru^{1

2}, Gianluca Pontone^{3

4}, Ruxandra Jurcut⁵, Julien Magne^{6

7}, Erwan Donal⁸, Ivan Stankovic⁹, Constantinos Anagnostopoulos¹⁰, Philipp E Bartko¹¹, Bart Bijnens^{12

13}, Marianna Fontana¹⁴, Elena Galli⁸, Blazej Michalski¹⁵, Martina Perazzolo Marra¹⁶, Théo Pezel¹⁷, Alexia Rossi^{18

19}, Otto A Smiseth²⁰, Nico Van de Veire^{21

22}, Thor Edvardsen²³, Steffen E Petersen^{24

25}, Bernard Cosyns²⁶, Daniele Andreini, Philippe Bertrand, Victoria Delgado, Marc Dweck, Kristina Haugaa, Niall Keenan, Thomas H Marwick, Danilo Neglia

Affiliations

¹ Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, 20126 Milan, Italy.
² Cardiovascular Imaging Center, Department of Cardiology, Istituto Auxologico Italiano, IRCCS, Piazzale Brescia 20, 20149 Milan, Italy.
³ Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Via Carlo Parea, 4, 20138 Milan, Italy.
⁴ Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
⁵ Institute of Emergency for Cardiovascular Diseases 'Prof. Dr. C.C. Iliescu', University of Medicine and Pharmacy 'Carol Davila', Șoseaua Fundeni 258, 022328 Bucharest, Romania.
⁶ Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of Chronic Diseases in Tropical Zone, OmegaHealth, CHU Limoges, Department of Cardiology, Limoges, France.
⁷ Center of Epidemiology, Biostatistics and Methodology of Research, CHU Limoges, Martin Luther King 2, 87042 Limoges, France.
⁸ Cardiology and CIC, University of Rennes, CHU Rennes, Inserm, LTSI-UMR 1099, 2 Rue Henri le Guilloux, 35000 Rennes, France.
⁹ Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Vukova 9, Belgrade, Serbia.
¹⁰ Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou St., 115 27 Athens, Greece.
¹¹ Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
¹² ICREA, Barcelona, Spain.
¹³ August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
¹⁴ National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
¹⁵ Department of Cardiology, Medical University of Lodz, al. Tadeusza Kościuszki 4, 90-419 Lodz, Poland.
¹⁶ Department of Cardiac, Thoracic, Vascular and Public Health, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.
¹⁷ Université de Paris-Cité, Service de Cardiologie, Hôpital Universitaire de Lariboisière, Assistance Publique-Hôpitaux de Paris (APHP), Inserm U-942, Paris, France.
¹⁸ Department of Nuclear Medicine, University Hospital, Rämistrasse 100, 8091 Zürich, Switzerland.
¹⁹ Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
²⁰ Institute for Surgical Research, Division of Cardiovascular and Pulmonary Diseases, Rikshospitalet, Oslo University Hospital, University of Oslo, N-0027 Oslo, Norway.
²¹ Department of Cardiology, AZ Maria Middelares, Buitenring-Sint-Denijs 30, 9000 Gent, Belgium.
²² Department of Cardiology, Vrije Universiteit Brussel, Bd de la Plaine 2, 1050 Ixelles, Brussels, Belgium.
²³ Department of Cardiology, Oslo University Hospital, Rikshospitalet and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
²⁴ William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK.
²⁵ Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, EC1A 7BE London, UK.
²⁶ Department of Cardiology, CHVZ (Centrum voor Hart en Vaatziekten), ICMI (In Vivo Cellular and Molecular Imaging) Laboratory, Universitair ziekenhuis Brussel, Brussel, Belgium.

PMID: 39226295
DOI: 10.1093/ehjci/jeae238

Free article

Practice Guideline

How to conduct clinical research in cardiovascular imaging: a primer for clinical cardiologists and researchers-a statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC

Denisa Muraru et al. Eur Heart J Cardiovasc Imaging. 2024.

Free article

. 2024 Dec 31;26(1):4-21.

doi: 10.1093/ehjci/jeae238.

Authors

Affiliations

¹ Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, 20126 Milan, Italy.
² Cardiovascular Imaging Center, Department of Cardiology, Istituto Auxologico Italiano, IRCCS, Piazzale Brescia 20, 20149 Milan, Italy.
³ Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Via Carlo Parea, 4, 20138 Milan, Italy.
⁴ Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
⁵ Institute of Emergency for Cardiovascular Diseases 'Prof. Dr. C.C. Iliescu', University of Medicine and Pharmacy 'Carol Davila', Șoseaua Fundeni 258, 022328 Bucharest, Romania.
⁶ Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of Chronic Diseases in Tropical Zone, OmegaHealth, CHU Limoges, Department of Cardiology, Limoges, France.
⁷ Center of Epidemiology, Biostatistics and Methodology of Research, CHU Limoges, Martin Luther King 2, 87042 Limoges, France.
⁸ Cardiology and CIC, University of Rennes, CHU Rennes, Inserm, LTSI-UMR 1099, 2 Rue Henri le Guilloux, 35000 Rennes, France.
⁹ Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Vukova 9, Belgrade, Serbia.
¹⁰ Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou St., 115 27 Athens, Greece.
¹¹ Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
¹² ICREA, Barcelona, Spain.
¹³ August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
¹⁴ National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
¹⁵ Department of Cardiology, Medical University of Lodz, al. Tadeusza Kościuszki 4, 90-419 Lodz, Poland.
¹⁶ Department of Cardiac, Thoracic, Vascular and Public Health, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.
¹⁷ Université de Paris-Cité, Service de Cardiologie, Hôpital Universitaire de Lariboisière, Assistance Publique-Hôpitaux de Paris (APHP), Inserm U-942, Paris, France.
¹⁸ Department of Nuclear Medicine, University Hospital, Rämistrasse 100, 8091 Zürich, Switzerland.
¹⁹ Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
²⁰ Institute for Surgical Research, Division of Cardiovascular and Pulmonary Diseases, Rikshospitalet, Oslo University Hospital, University of Oslo, N-0027 Oslo, Norway.
²¹ Department of Cardiology, AZ Maria Middelares, Buitenring-Sint-Denijs 30, 9000 Gent, Belgium.
²² Department of Cardiology, Vrije Universiteit Brussel, Bd de la Plaine 2, 1050 Ixelles, Brussels, Belgium.
²³ Department of Cardiology, Oslo University Hospital, Rikshospitalet and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
²⁴ William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK.
²⁵ Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, EC1A 7BE London, UK.
²⁶ Department of Cardiology, CHVZ (Centrum voor Hart en Vaatziekten), ICMI (In Vivo Cellular and Molecular Imaging) Laboratory, Universitair ziekenhuis Brussel, Brussel, Belgium.

PMID: 39226295
DOI: 10.1093/ehjci/jeae238

Abstract

This statement from the European Association of Cardiovascular Imaging (EACVI) of the ESC aims to address the fundamental principles that guide clinical research in the field of cardiovascular imaging. It provides clinical researchers, cardiology fellows, and PhD students with a condensed, updated, and practical reference document to support them in designing, implementing, and conducting imaging protocols for clinical trials. Although the present article cannot replace formal research training and mentoring, it is recommended reading for any professional interested in becoming acquainted with or participating in clinical trials involving cardiovascular imaging.

Keywords: cardiovascular imaging; clinical trials; research; research methodology; study design.

© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Conflict of interest statement

Conflict of interest: None declared.

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How to conduct clinical research in cardiovascular imaging: a primer for clinical cardiologists and researchers-a statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC

Affiliations

How to conduct clinical research in cardiovascular imaging: a primer for clinical cardiologists and researchers-a statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources