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. 2024 Oct;16(10):2274-2275.
doi: 10.1038/s44321-024-00124-z. Epub 2024 Sep 3.

Can we manipulate the ovary's own metabolism to protect it from chemotherapy-induced damage?

Adomas Liugaila  1 , Agnes Stefansdottir  1 , Norah Spears  2
Affiliations

Can we manipulate the ovary's own metabolism to protect it from chemotherapy-induced damage?

Adomas Liugaila et al. EMBO Mol Med. 2024 Oct.

Abstract

Some chemotherapy treatments induce female infertility through accelerated ovarian ageing, including due to nicotinamide adenine dinucleotide (NAD) depletion. Using various mouse models, Ho et al (2024) demonstrate that exposure to two such chemotherapy drugs, cisplatin or doxorubicin, deplete ovarian NAD, with levels restored by administrating the exogenous NAD precursor nicotinamide mononucleotide, ameliorating the drugs’ damaging effects on fertility.

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Conflict of interest statement

The authors declare no competing interests.

References

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    1. Ho WHJ, Marinova MB, Listijono DR, Bertoldo MJ, Richani D, Kim L, Brown A, Riepsamen AH, Cabot S, Frost ER et al (2024) Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome. EMBO Mol Med. 10.1038/s44321-024-00119-w - PMC - PubMed
    1. Spears N, Lopes F, Stefansdottir A, Rossi V, De, Felici M, Anderson RA, Klinger FG (2019) Ovarian damage from chemotherapy and current approaches to its protection. Hum Reprod Update 25:673–693 - PMC - PubMed

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