Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
[Preprint]. 2024 Aug 22:2024.08.22.24312434.
doi: 10.1101/2024.08.22.24312434.

Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxy-PEP-Eligible Population

Rachel Mittelstaedt  1   2 , Sanjat Kanjilal  3   4 , David Helekal  2 , Gregory K Robbins  1 , Yonatan H Grad  2
Affiliations

Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxy-PEP-Eligible Population

Rachel Mittelstaedt et al. medRxiv. .

Update in

Abstract

In Staphylococcus aureus infections in men eligible for doxycycline post-exposure prophylaxis (doxy-PEP), tetracycline non-susceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for S. aureus multi-drug resistance, underscoring the importance of surveillance.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2022. Atlanta: U.S. Department of Health and Human Services; 2024.
    1. Luetkemeyer AF, Donnell D, Dombrowski JC, et al. Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections. N Engl J Med. 2023;388(14):1296–1306. doi:10.1056/NEJMoa2211934 - DOI - PMC - PubMed
    1. Bachmann LH, Barbee LA, Chan P, et al. CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024. MMWR Recomm Rep. 2024;73(2):1–8. doi:10.15585/mmwr.rr7302a1 - DOI - PMC - PubMed
    1. Jo JH, Harkins CP, Schwardt NH, et al. Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics. Sci Transl Med. 2021;13(625):eabd8077. doi:10.1126/scitranslmed.abd8077 - DOI - PMC - PubMed
    1. Kenyon C. Doxycycline post-exposure prophylaxis could theoretically select for resistance to various antimicrobials in 19 pathobionts: an in silico analysis. International Journal of Infectious Diseases. 2024;142:106974. doi:10.1016/j.ijid.2024.02.017 - DOI - PubMed

Publication types

LinkOut - more resources