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. 2024 Dec;31(12):e16461.
doi: 10.1111/ene.16461. Epub 2024 Sep 4.

Nonamyloidogenic TTR gene variants c.76G>A and c.337-18G>C are not associated with idiopathic small-fiber neuropathy

Céline Konecki  1 , Bruno Francou  1 , Kenneth Chappell  1 , Lucie Augey  1 , Guillemette Beaudonnet  2 , Cécile Cauquil  2   3 , Dalia Dimitri-Boulos  3 , Adeline Not  3 , Clovis Adam  2 , Vianney Poinsignon  1 , Céline Verstuyft  1 , David Adams  2   3 , Andoni Echaniz-Laguna  2   3 , Céline Labeyrie  2   3
Affiliations

Nonamyloidogenic TTR gene variants c.76G>A and c.337-18G>C are not associated with idiopathic small-fiber neuropathy

Céline Konecki et al. Eur J Neurol. 2024 Dec.

Abstract

Background and purpose: Small-fiber neuropathy (SFN) affects only unmyelinated and thin myelinated fibers. It may be caused by amyloidogenic mutations of the transthyretin (TTR) gene, but not all TTR gene variants are pathogenic. The nonamyloidogenic c.76G>A (rs1800458) and c.337-18G>C (rs36204272) variants of TTR were recently reported to be associated with SFN. We investigated this putative association by analyzing TTR gene sequencing data retrospectively for two cohorts of patients, one with SFN and a control group.

Methods: In this retrospective single-center study, we analyzed the frequency of the c.76G>A and c.337-18G>C TTR gene variants in a cohort of patients meeting a strict definition of SFN, with or without dysautonomia, a control cohort of patients investigated for nonneurological conditions, and the gnomAD international database.

Results: We included 55 SFN patients in this study, 17 of whom had dysautonomia. The allelic frequencies of the two variants in our cohort of 55 SFN patients were 7.27% for c.76G>A TTR and 5.25% for c.337-18G>C. The frequencies of both variants were statistically similar in the 337 control patients and the gnomAD database.

Conclusions: The c.76G>A and c.337-18G>C TTR gene variants are not associated with SFN.

Keywords: TTR; amyloidosis; small‐fiber neuropathy; variants.

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Conflict of interest statement

None of the authors has any conflict of interest to disclose.

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