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. 2024 Dec;193(6):2669-2679.
doi: 10.1007/s11845-024-03793-4. Epub 2024 Sep 4.

The incidence of incidental neoplasia in pathology samples of patient who underwent appendectomy due to acute appendicitis. A single center experience: 6446 cases

Nurettin Sahin  1 , Ferman Tevfik Ozyalvac  2 , Turgut Donmez  2 , Ahmet Surek  2 , Emine Ayca Sahin  3 , Goker Calis  2 , Sezer Bulut  2 , Husnu Aydin  2 , Hamit Ahmet Kabuli  2 , Alpen Yahya Gumusoglu  2
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The incidence of incidental neoplasia in pathology samples of patient who underwent appendectomy due to acute appendicitis. A single center experience: 6446 cases

Nurettin Sahin et al. Ir J Med Sci. 2024 Dec.

Abstract

Purpose: Appendectomy is the standard treatment of acute appendicitis. However, recent advancements have introduced medical treatment as a potential alternative. Within this context, it's important to recognize the rare occurrence of appendiceal tumors, often incidentally discovered during histopathological examination following appendectomy. Consequently, there's a concern about the possibility of overlooking appendiceal neoplasms, particularly in cases where conservative treatment for acute appendicitis is considered.

Methods: The files of patients who underwent surgery for acute appendicitis between January 2015 and December 2023 and were diagnosed with neoplasia in their pathology reports were retrospectively registered. Demographic characteristics of the patients, laboratory and imaging features, details of the surgery performed, preoperative and intraoperative suspicion of neoplasm and data from pathology reports were collected and analyzed.

Results: A total of 6446 patients were operated for acute appendicitis. Neoplasia was detected in the histopathological examination of 93 patients (1.44%). Acute appendicitis was diagnosed in 51.6% of the patients by computed tomography. Neoplasm suspicion was present in 9.7% of patients in preoperative imaging methods and in 6.5% of patients intraoperatively. Only appendectomy was performed in 94.5% of patients. The most common appendiceal neoplasm is neuroendocrine tumors (40.9%), followed by appendiceal mucinous neoplasm (29%), sessile serrated adenoma (15%), and adenocarcinoma (6.5%).

Conclusion: Although appendiceal neoplasms are relatively rare in proportion, they represent a significant numerical value due to the density of cases. Therefore, this information should be taken into consideration when evaluating treatment options for acute appendicitis.

Keywords: Acute appendicitis; Appendectomy; Neoplasia.

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Conflict of interest statement

Declarations. Consent to participate: Informed consent was obtained from all individual participants of the study. Competing interest: The authors declare no competing interests. Human and animal rights: All procedures performed in this study involving human participants were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any study with animals performed by any of the authors.

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