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Case Reports
. 2024 Oct 1;160(10):1125-1128.
doi: 10.1001/jamadermatol.2024.2921.

Genetic Aspects of Necrobiotic Xanthogranuloma

Peng-Yu Chen  1 , Zhuang-Li Tang  1 , Yuan-Yu Hong  1 , I-Jung Hsieh  1 , Zi-Yun Li  1 , Jiong Zhou  1 , Sui-Qing Cai  1
Affiliations
Case Reports

Genetic Aspects of Necrobiotic Xanthogranuloma

Peng-Yu Chen et al. JAMA Dermatol. .
No abstract available

Plain language summary

This genetic association study examines the genetic aspects of necrobiotic xanthogranuloma in 3 patients in China.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Periorbital Lesions in 3 Patients and the Hypothesized Partial Mechanism of Necrobiotic Xanthogranuloma (NXG) Associated With ABCG5/G8 Variants
D-F, Histopathologic examination showed palisading granulomas (black arrowhead) in with lymphoplasmacytic infiltration and zones of necrobiosis (asterisk) (D), abundant peripheral foam cells (yellow arrowhead) (E), and Touton giant cells (blue arrowhead) (F) (hematoxylin-eosin; bars: 500 μm [D and E] and 250 μm [F]). G, The hypothesized partial mechanism of NXG associated with ABCG5/G8 variants involves cellular sterol accumulation and decreased high-density lipoprotein (HDL) concentrations, which lead to impaired reverse cholesterol transport (RCT), inflammatory responses, and the migration of monocytes from peripheral blood to the skin, ultimately resulting in disrupted macrophage-lipid homeostasis. This diagram was created with BioRender.com. ABCG indicates adenosine triphosphate–binding cassette subfamily G; CCR, chemokine receptor; ICAM-1, intercellular adhesion molecule 1; IL, interleukin; MCP-1, membrane cofactor protein 1; MIP-1α, macrophage inflammatory protein 1α; TNF, tumor necrosis factor; VCAM-1, vascular cellular adhesion molecule 1.
See this image and copyright information in PMC

References

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