Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Sep 4;22(9):e3002788.
doi: 10.1371/journal.pbio.3002788. eCollection 2024 Sep.

High temperatures increase the virulence of Vibrio bacteria towards their coral host and competing bacteria via type VI secretion systems

Affiliations
Comment

High temperatures increase the virulence of Vibrio bacteria towards their coral host and competing bacteria via type VI secretion systems

Weiquan Wang et al. PLoS Biol. .

Abstract

The bacterial pathogen Vibrio coralliilyticus induces severe coral diseases in warming oceans. A study in PLOS Biology reveals that high temperatures activate 2 type VI secretion systems in V. coralliilyticus, enhancing pathogenicity by deploying toxic effectors against competing bacteria and coral cells.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic depicting interactions between coral pathogen, cohabiting bacteria, and coral host.
Activation of 2 T6SS systems at elevated ocean temperatures enhances V. coralliilyticus pathogenic potential by secreting antibacterial effectors to kill bacterial competitors and secreting anti-eukaryotic effectors.

Comment on

References

    1. Vezzulli L, Grande C, Reid PC, Helaouët P, Edwards M, Höfle MG, et al.. Climate influence on Vibrio and associated human diseases during the past half-century in the coastal North Atlantic. Proc Natl Acad Sci U S A. 2016;113(34):E5062–E5071. doi: 10.1073/pnas.1609157113 ; PubMed Central PMCID: PMC5003230. - DOI - PMC - PubMed
    1. Kimes NE, Grim CJ, Johnson WR, Hasan NA, Tall BD, Kothary MH, et al.. Temperature regulation of virulence factors in the pathogen Vibrio coralliilyticus. ISME J. 2012;6(4):835–846. doi: 10.1038/ismej.2011.154 ; PubMed Central PMCID: PMC3309362. - DOI - PMC - PubMed
    1. Colwell RR. Global climate and infectious disease: The cholera paradigm. Science. 1996;274(5295):2025–2031. doi: 10.1126/science.274.5295.2025 . - DOI - PubMed
    1. Ben-Haim Y, Zicherman-Keren M, Rosenberg E. Temperature-regulated bleaching and lysis of the coral Pocillopora damicornis by the novel pathogen Vibrio coralliilyticus. Appl Environ Microbiol. 2003;69(7):4236–4242. doi: 10.1128/AEM.69.7.4236-4242.2003 ; PubMed Central PMCID: PMC165124. - DOI - PMC - PubMed
    1. Wang WQ, Tang KH, Wang PX, Zeng ZS, Xu T, Zhan W, et al.. The coral pathogen Vibrio coralliilyticus kills non-pathogenic holobiont competitors by triggering prophage induction. Nat Ecol Evol. 2022;6(8):1132–1144. doi: 10.1038/s41559-022-01795-y . - DOI - PubMed

Substances

Supplementary concepts

LinkOut - more resources