Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1985 Apr;48(4):374-7.
doi: 10.1136/jnnp.48.4.374.

The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin

P N Patsalos, S D Shorvon, A A Elyas, G Smith
Clinical Trial

The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin

P N Patsalos et al. J Neurol Neurosurg Psychiatry. 1985 Apr.

Abstract

Denzimol, a new anticonvulsant drug, is currently undergoing clinical evaluation. In this paper we report its use in six patients who were also taking carbamazepine and two patients taking phenytoin. There was a striking elevation of serum carbamazepine, carbamazepine-10, 11 epoxide and phenytoin concentrations in all patients on the addition of denzimol therapy. The interaction with carbamazepine is greater in severity than any other reported to date and denzimol's interaction with both carbamazepine and phenytoin is likely to prove of major clinical significance.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Epilepsia. 1968 Mar;9(1):17-22 - PubMed
    1. Epilepsia. 1977 Jun;18(2):169-82 - PubMed
    1. Acta Neurol Scand. 1977 Dec;56(6):603-7 - PubMed
    1. Epilepsia. 1980 Oct;21(5):489-96 - PubMed
    1. Arzneimittelforschung. 1983;33(8):1168-73 - PubMed

Publication types

MeSH terms

LinkOut - more resources