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. 2024 Sep 4;44(36):e0961242024.
doi: 10.1523/JNEUROSCI.0961-24.2024.

Sex-Dependent Synaptic Alterations in a Mouse Model of Alzheimer's Disease

Brittany J Dugan  1 , Myles Dockery  2
Affiliations

Sex-Dependent Synaptic Alterations in a Mouse Model of Alzheimer's Disease

Brittany J Dugan et al. J Neurosci. .
No abstract available

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
In a mouse model of AD, female mice demonstrate increased amyloid burden and fewer presynaptic connections to the subiculum. At both young and older ages, female 5xFAD mice demonstrated a larger density, size, and intensity of pathological amyloid in the subiculum compared with male mice of the same age. Moreover, female mice showed a more severe deficit in presynaptic projections to the subiculum, suggesting that female mice may have a more severe course of disease.
See this image and copyright information in PMC

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