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Review
. 2024 Sep 5;41(10):240.
doi: 10.1007/s12032-024-02481-8.

The role of IL-22 in cancer

Zachary E Hunzeker #  1   2   3 , Lei Zhao #  4 , Austin M Kim  1 , Jacob M Parker  1 , Ziwen Zhu  2 , Huaping Xiao  1   2 , Qian Bai  2 , Mark R Wakefield  2   5 , Yujiang Fang  6   7   8
Affiliations
Review

The role of IL-22 in cancer

Zachary E Hunzeker et al. Med Oncol. .

Abstract

Interleukin-22, discovered in the year of 2000, is a pleiotropic Th17 cytokine from the IL-10 family of cytokines. IL-22 signals through the type 2 cytokine receptor complex IL-22R and predominantly activates STAT3. This pathway leads to the transcription of several different types of genes, giving IL-22 context-specific functions ranging from inducing antimicrobial peptide expression to target cell proliferation. In recent years, it has been shown that IL-22 is involved in the pathogenesis of neoplasia in some cancers through its pro-proliferative and anti-apoptotic effects. This review highlights studies with recent discoveries and conclusions drawn on IL-22 and its involvement and function in various cancers. Such a study may be helpful to better understand the role of IL-22 in cancer so that new treatment could be developed targeting IL-22.

Keywords: Cytokine; Interleukin-22; Tumor.

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