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Review
. 2024 Oct:52:101129.
doi: 10.1016/j.currproblcancer.2024.101129. Epub 2024 Sep 3.

Theranostics in Neuroendocrine Tumors: Updates and Emerging Technologies

Nadine Mallak  1 , Burcak Yilmaz  1 , Catherine Meyer  2 , Celeste Winters  2 , Anna Mench  2 , Abhinav K Jha  3 , Vikas Prasad  4 , Erik Mittra  5
Affiliations
Review

Theranostics in Neuroendocrine Tumors: Updates and Emerging Technologies

Nadine Mallak et al. Curr Probl Cancer. 2024 Oct.

Abstract

Advancements in somatostatin receptor (SSTR) targeted imaging and treatment of well-differentiated neuroendocrine tumors (NETs) have revolutionized the management of these tumors. This comprehensive review delves into the current practice, discussing the use of the various FDA-approved SSTR-agonist PET tracers and the predictive imaging biomarkers, and elaborating on Lu177-DOTATATE peptide receptor radionuclide therapy (PRRT) including the evolving areas of post-therapy imaging practices, PRRT retreatment, and the potential role of dosimetry in optimizing patient treatments. The future directions sections highlight ongoing research on investigational PET imaging radiotracers, future prospects in alpha particle therapy, and combination therapy strategies.

Keywords: DOTATATE; NETs; dosimetry; somatostatin receptor; theranostics.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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