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Review
. 2024 Oct:208:107394.
doi: 10.1016/j.phrs.2024.107394. Epub 2024 Sep 3.

Investigating the interplay between mitophagy and diabetic neuropathy: Uncovering the hidden secrets of the disease pathology

Kiavash Hushmandi  1 , Behzad Einollahi  2 , Rachel Aow  3 , Suhana Binte Suhairi  3 , Daniel J Klionsky  4 , Amir Reza Aref  5 , Russel J Reiter  6 , Pooyan Makvandi  7 , Navid Rabiee  8 , Yi Xu  9 , Noushin Nabavi  10 , Seyed Hassan Saadat  2 , Najma Farahani  11 , Alan Prem Kumar  12
Affiliations
Review

Investigating the interplay between mitophagy and diabetic neuropathy: Uncovering the hidden secrets of the disease pathology

Kiavash Hushmandi et al. Pharmacol Res. 2024 Oct.

Abstract

Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a crucial role in maintaining metabolic balance and preventing insulin resistance, both key factors in type 2 diabetes mellitus (T2DM) development. When mitophagy malfunctions in diabetic neuropathy, it triggers a cascade of metabolic disruptions, including reduced energy production, increased oxidative stress, and cell death, ultimately leading to various complications. Thus, targeting mitophagy to enhance the process may have emerged as a promising therapeutic strategy for T2DM and its complications. Notably, plant-derived compounds with β-cell protective and mitophagy-stimulating properties offer potential as novel therapeutic agents. This review highlights the intricate mechanisms linking mitophagy dysfunction to T2DM and its complications, particularly neuropathy, elucidating potential therapeutic interventions for this debilitating disease.

Keywords: Diabetic neuropathies; Mitochondria; Mitophagy; Type 2 diabetes mellitus.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
Diabetic neuropathy: Epidemiology, prevalence, and pathogenesis.
Figure 2.
Figure 2.
Mitochondrion: Structure and functions.
Figure 3.
Figure 3.
Mitophagy and its underlying mechanisms.
Figure 4.
Figure 4.
Mitophagy and cellular homeostasis versus cell death. GSH: reduced glutathione; GSSG: glutathione disulfide; LPS: lipopolysaccharide; SCAF11: SR-related CTD associated factor 11; TNFRSF: TNF receptor superfamily.
See this image and copyright information in PMC

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