Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep;85(6):e22259.
doi: 10.1002/ddr.22259.

Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5-HT2A and D2 receptor interaction pathways

Muhammad Torequl Islam  1   2   3 , Raihan Chowdhury  2   3 , Md Shimul Bhuia  2   3 , Brototi Chakrabarty  4 , Neloy Kundu  1 , Md Showkot Akbor  2 , Salehin Sheikh  2   3 , Rokibul Islam Chowdhury  2   3 , Siddique Akber Ansari  5 , Irfan Aamer Ansari  6 , Md Amirul Islam  1   7
Affiliations

Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5-HT2A and D2 receptor interaction pathways

Muhammad Torequl Islam et al. Drug Dev Res. 2024 Sep.

Abstract

Schizophrenia affects identification and disturbs our thinking and motivational capacity. Long-term use of daidzin (DZN) is evident to enhance attention and memory in experimental animals. This study aimed to investigate the effect of DZN on Swiss mice. To check animals' attention, identification, thinking, and motivational ability, we performed behavioral studies using marble burying, dust removal, and trained swimming protocols. For this, a total of 36 male Swiss albino mice were randomly divided into six groups, consisting of 6 animals in each group, as follows: control (vehicle), DZN-1.25, DZN-2.5, DZN-5 mg/kg, olanzapine (OLN)-2, and a combination of DZN-1.25 with OLN-2. Additionally, in silico studies are also performed to understand the possible molecular mechanisms behind this neurological effect. Findings suggest that DZN dose-dependently and significantly (p < .05) increased marble burying and removed dust while reducing the time to reach the target point. DZN-1.25 was found to enhance OLN's effect significantly (p < .05), possibly via agonizing its activity in animals. In silico findings suggest that DZN has strong binding affinities of -10.1 and -10.4 kcal/mol against human serotonin 2 A (5-HT2A) and dopamine 2 (D2) receptors, respectively. Additionally, DZN exhibits favorable pharmacokinetic and toxicity properties. We suppose that DZN may exert its attention- and memory-enhancing abilities by interacting with 5-HT2A and D2 receptors. It may exert a synergistic antischizophrenia-like effect with the standard drug, OLN. Further studies are required to discover the exact molecular mechanism for this neurological function in animals.

Keywords: daidzin; memory‐enhancing ability; schizophrenia; serotoninergic system, dopaminergic interaction.

PubMed Disclaimer

References

REFERENCES

    1. Albert, P. R., & Le François, B. J. F. in (2010). Modifying 5‐HT1A receptor gene expression as a new target for antidepressant therapy (Vol. 4, p. 1762).
    1. Antunes, M., & Biala, G. (2012). The novel object recognition memory: neurobiology, test procedure, and its modifications. Cognitive processing, 13, 93–110.
    1. Archer, T., Fredriksson, A., Lewander, T., & SÖDerberg, U. (1987). Marble burying and spontaneous motor activity in mice: Interactions over days and the effect of diazepam. Scandinavian Journal of Psychology, 28(3), 242–249.
    1. Barbosa Filho, J. M., Medeiros, K. C. P., Diniz, M. d. F. F., Batista, L. M., Athayde‐Filho, P. F., Silva, M. S., & Quintans‐Júnior, L. J. J. R. B. d. F. (2006). Produtos Naturais Inibidores Da Enzima Acetilcolinesterase (Vol. 16, pp. 258–285).
    1. Blasi, G., Selvaggi, P., Fazio, L., Antonucci, L. A., Taurisano, P., Masellis, R., Romano, R., Mancini, M., Zhang, F., Caforio, G., Popolizio, T., Apud, J., Weinberger, D. R., & Bertolino, A. (2015). Variation in dopamine D2 and serotonin 5‐HT2A receptor genes is associated with working memory processing and response to treatment with antipsychotics. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 40(7), 1600–1608.

LinkOut - more resources