Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Aug 5;16(8):e66167.
doi: 10.7759/cureus.66167. eCollection 2024 Aug.

Amyloid Goiter in a 57-Year-Old Woman With Chronic Kidney Disease: A Case Report

A Rahman Farahat  1 , Mahera Roohi  1
Affiliations
Case Reports

Amyloid Goiter in a 57-Year-Old Woman With Chronic Kidney Disease: A Case Report

A Rahman Farahat et al. Cureus. .

Abstract

Amyloid goiter (AG) is a condition in which amyloid protein builds up in the thyroid gland. Patients with such a condition tend to have thyroid tissue that is extensively involved by amyloid; however, patients are usually euthyroid. Systemic amyloidosis is one of the conditions that may cause damage to the kidneys or worsen the condition of kidney failure in patients with ongoing chronic kidney disease as amyloid proteins can deposit in a variety of tissues including kidneys. Thyroid goiter can rarely be the first confirmed place to be involved with amyloidosis. We present the case of a 57-year-old female with AG who had a history of renal failure.

Keywords: amyloid deposition; amyloid goiter; amyloidosis; chronic kidney disease; thyroid gland.

PubMed Disclaimer

Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Left thyroid lobe ultrasonography showing a suspicious nodule
Figure 2
Figure 2. Follow-up ultrasound showing enlargement of the ill-defined left lobe nodule
Figure 3
Figure 3. Left lobe hypoechoic nodule (lateral to the previous cystic nodule)
Figure 4
Figure 4. Hematoxylin-eosin stain x10: Intrathyroidal fatty metaplasia, slightly dilated follicles filled with colloid
Figure 5
Figure 5. Hematoxylin-eosin stain x20: amorphous material deposits
Figure 6
Figure 6. Amyloid-P IHC showing positivity
Figure 7
Figure 7. Congo red stain at 20x: showing apple-green birefringence (black arrows) under polarized microscopy
See this image and copyright information in PMC

References

    1. Carl von Rokitansky and the Italian translation of the Handbuch der Pathologischen Anatomie: a linguistic and doctrinal enigma. Castagnoli L, Jonjic N, Rizzardi C, Melato M. https://pubmed.ncbi.nlm.nih.gov/11785117/ Pathologica. 2001;93:654–661. - PubMed
    1. Amyloid goiter. Villa F, Dionigi G, Tanda ML, Rovera F, Boni L. Int J Surg. 2008;6 Suppl 1:0–8. - PubMed
    1. Amyloid goiter: a case report and review of the literature. Jakubović-Čičkušić A, Hasukić B, Sulejmanović M, Čičkušić A, Hasukić Š. Saudi J Med Med Sci. 2020;8:151–155. - PMC - PubMed
    1. Current treatment of AL amyloidosis. Palladini G, Merlini G. Haematologica. 2009;94:1044–1048. - PMC - PubMed
    1. Dialysis-related amyloidosis: challenges and solutions. Scarpioni R, Ricardi M, Albertazzi V, De Amicis S, Rastelli F, Zerbini L. Int J Nephrol Renovasc Dis. 2016;9:319–328. - PMC - PubMed

Publication types

LinkOut - more resources