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Case Reports
. 2024 Aug;24(3):415-417.
doi: 10.18295/squmj.6.2024.036. Epub 2024 Aug 29.

Blastic Plasmacytoid Dendritic Cell Neoplasm

Affiliations
Case Reports

Blastic Plasmacytoid Dendritic Cell Neoplasm

Dmitry V Kravchenko et al. Sultan Qaboos Univ Med J. 2024 Aug.
No abstract available

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Figures

Figure 1
Figure 1
A: Blastic plasmacytoid dendritic cell neoplasm presenting as an erythematous papule on the skin. B: Haematoxylin and eosin stain at ×200 magnification showing small-to-medium-sized neoplastic blasts with fine chromatin and scanty cytoplasm. C: Positron emission tomography-computed tomography scan showing multiple 18F-FDG-avid foci in the breast tissues and inguinal lymph node.
Figure 2
Figure 2
HRP-polymer-based immunohistochemistry showing strong CD45 and CD43, along with moderate CD56 expression. The majority of cells are expressing TdT. Counterstain: Meyer’s haematoxylin at magnification ×200.
Figure 3
Figure 3
Flow cytometry of the bone marrow demonstrating hematogenous dissemination with presence of neoplastic cells in the peripheral blood.

References

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    1. Sapienza MR, Pileri A, Derenzini E, Melle F, Motta G, Fiori S, et al. Blastic plasmacytoid dendritic cell neoplasm: State of the art and prospects. Cancers (Basel) 2019;11:595. doi: 10.3390/cancers11050595. - DOI - PMC - PubMed
    1. Safaei A, Monabati A, Mokhtari M, Solhjoo F, Montazer M. Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases. Iran J Med Sci. 2019;44:74–8. - PMC - PubMed
    1. Goel D, Bhargava R. Blastic plasmacytoid dendritic cell neoplasm. A rare hematodermic malignancy. Hematol Transfus Cell Ther. 2020;42:384–6. doi: 10.1016/j.htct.2019.10.006. - DOI - PMC - PubMed
    1. Adimora IJ, Wilson NR, Pemmaraju N. Blastic plasmacytoid dendritic cell neoplasm (BPDCN): A promising future in the era of Targeted therapeutics. Cancer. 2022;128:3019–26. doi: 10.1002/cncr.34345. - DOI - PubMed

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