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. 2024 Jun 4;6(3):266-272.
doi: 10.1016/j.smhs.2024.06.001. eCollection 2024 Sep.

Effects of COVID-19 on the cardiovascular system: A mendelian randomization study

Qingzhi Ran  1 , Aoshuang Li  2 , Rui Li  3 , Yuyang Dong  4 , Xue Xiao  3 , Kun Wang  3 , Hengwen Chen  1 , Benxiang He  3
Affiliations

Effects of COVID-19 on the cardiovascular system: A mendelian randomization study

Qingzhi Ran et al. Sports Med Health Sci. .

Abstract

Infections with the coronavirus disease 2019 (COVID-19) and disorders of the heart and blood vessels are causally related. To ascertain the causal relationship between COVID-19 and cardiovascular disease (CVD), we carried out a Mendelian randomization (MR) study through a method known as inverse variance weighting (IVW). When analyzing multiple SNPs, MR can meta-aggregate the effects of multiple loci by using IVW meta-pooling method. The weighted median (WM) is the median of the distribution function obtained by ranking all individual SNP effect values according to their weights. WM yields robust estimates when at least 50% of the information originates from valid instrumental variables (IVs). Directed gene pleiotropy in the included IVs is permitted because MR-Egger does not require a regression straight line through the origin. For MR estimation, IVW, WM and MR-Egger were employed. Sensitivity analysis was conducted using funnel plots, Cochran's Q test, MR-Egger intercept test, MR-PRESSO, and leave-one-out analysis. SNPs related to exposure to COVID-19 and CVD were compiled. CVD for COVID-19 infection, COVID-19 laboratory/self-reported negative, and other very severe respiratory diagnosis and population were randomly assigned using MR. The COVID-19 laboratory/self-reported negative results and other very severe respiratory confirmed cases versus MR analysis of CVD in the population (p ​> ​0.05); COVID-19 infection to CVD (p ​= ​0.033, OR ​= ​1.001, 95%CI: 1.000-1.001); and the MR-Egger results indicated that COVID-19 infection was associated with CVD risk. This MR study provides preliminary evidence for the validity of the causal link between COVID-19 infection and CVD.

Keywords: COVID-19; Cardiovascular disease; GWAS; Genome-wide association studies; Mendelian randomization (MR).

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Conflict of interest statement

Benxiang He is an editorial board member for Sports Medicine and Health Science and was not involved in the editorial review or the decision to publish this article. Otherwise, authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Graphical representation of the three main hypotheses of Mendelian randomization studies Note: MR, Mendelian randomization. IVW, inverse variance-weighted. WM, weighted median.MR-Egger, MR-Egger regression.SM, simple mode. WM2, weighted mode.
Fig. 2
Fig. 2
Scatterplot of Mendelian randomization between COVID-19 and CVD, leave-one-out method, and resultant plots.
See this image and copyright information in PMC

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