Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jun;82(11):3894-6.
doi: 10.1073/pnas.82.11.3894.

The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie

B H Toh, C J Gibbs Jr, D C Gajdusek, D D Tuthill, D Dahl

The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie

B H Toh et al. Proc Natl Acad Sci U S A. 1985 Jun.

Abstract

Sera from 46 chimpanzees with spongiform encephalopathy (18 kuru, 28 Creutzfeldt-Jakob disease) and sera from 12 sheep with natural scrapie were tested for reactivity with immunoblots of neurofilament preparations obtained from mouse brain. The sera from the chimpanzees reacted mainly with the 200- and 150-kDa proteins of the neurofilament triplet and less frequently with the 70-kDa component of the triplet and with a 62-kDa neurofilament-associated protein. In contrast, the sera of sheep with natural scrapie reacted exclusively against the 62-kDa protein. The specificity of the reactions was established by comparison of sera reactivities with those of rabbit and mouse polyclonal antibodies and mouse monoclonal antibody to neurofilament proteins.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Jan;77(1):653-7 - PubMed
    1. Science. 1980 Oct 10;210(4466):190-3 - PubMed
    1. Acta Neuropathol. 1981;54(1):63-74 - PubMed