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. 2025 Mar;14(8):e2401994.
doi: 10.1002/adhm.202401994. Epub 2024 Sep 5.

Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease

Seungmin Baik  1   2 , Hyunmin Kim  3   4 , Yunjung Lee  1   2 , Taegyu Kang  1   2 , Kwangsoo Shin  1   2 , Changyeong Song  1   2 , Ok Kyu Park  2   5 , Byeonggeun Kang  6 , Nohyun Lee  2   7 , Dokyoon Kim  2   8 , Seung Hong Choi  2   5   9 , Seung Han Kim  10 , Min Soh  1   9 , Taeghwan Hyeon  1   2 , Chi Kyung Kim  3   4
Affiliations

Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease

Seungmin Baik et al. Adv Healthc Mater. 2025 Mar.

Abstract

Ceria-based nanoparticles are versatile in treating various inflammatory diseases, but their feasibility in clinical translation is undermined by safety concerns and a limited delivery system. Meanwhile, the idiopathic nature of inflammatory bowel disease (IBD) calls for a wider variety of therapeutics via moderation of the intestinal immune system. In this regard, the synthesis and oral formulation of iron-ceria nanoparticles (CF NPs) with enhanced nanozymic activity and lower toxicity risk than conventional ceria-based nanoparticles are reported. CF NPs are clustered in calcium phosphate (CaP) and coated with a pH-responsive polymer to provide the enteric formulation of iron-ceria nanotablets (CFNT). CFNT exhibits a marked alleviative efficacy in the dextran sodium sulfate (DSS)-induced enterocolitis model in vivo by modulating the pro-inflammatory behavior of innate immune cells including macrophages and neutrophils, promoting anti-inflammatory cytokine profiles, and downregulating key transcription factors of inflammatory pathways.

Keywords: anti‐inflammations; enteric delivery; inflammatory bowel diseases; iron‐ceria nanoparticles; nanomedicines.

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