[Biological activity of thiophosphamide-alkylated DNA in the transformation system of Bacillus subtilis]
[Article in
Russian]
- PMID: 3923671
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[Biological activity of thiophosphamide-alkylated DNA in the transformation system of Bacillus subtilis]
[Article in
Russian]
Tsitol Genet.
1985 Mar-Apr.
Abstract
DNA treated with thiophosphamide was studied for changes in its biological activity in transformation system of Bac. subtilis. DNA alkylation by this three-functional alkylating agent is shown to be followed by the reduction of transforming activity, changes in the competitive ability as well as by a decrease of the cotransfer coefficient for linked markers of transforming DNA. The observed changes in the transforming and cotransforming activities may be explained by variations in the DNA structure.
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