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. 1985 Mar-Apr;19(2):141-4.

[Biological activity of thiophosphamide-alkylated DNA in the transformation system of Bacillus subtilis]

[Article in Russian]
O E Kitam, T N Shevchenko
  • PMID: 3923671

[Biological activity of thiophosphamide-alkylated DNA in the transformation system of Bacillus subtilis]

[Article in Russian]
O E Kitam et al. Tsitol Genet. 1985 Mar-Apr.

Abstract

DNA treated with thiophosphamide was studied for changes in its biological activity in transformation system of Bac. subtilis. DNA alkylation by this three-functional alkylating agent is shown to be followed by the reduction of transforming activity, changes in the competitive ability as well as by a decrease of the cotransfer coefficient for linked markers of transforming DNA. The observed changes in the transforming and cotransforming activities may be explained by variations in the DNA structure.

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