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. 2024 Oct;47(10):751-752.
doi: 10.1016/j.tins.2024.08.014. Epub 2024 Sep 4.

Unweaving type I interferons in age-related neuroinflammation

David P J Hunt  1 , Markus J Hofer  2
Affiliations

Unweaving type I interferons in age-related neuroinflammation

David P J Hunt et al. Trends Neurosci. 2024 Oct.

Abstract

Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.

Keywords: RNA sequencing; brain aging; dementia; mouse model; neurodegeneration; neuroimmune.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests in relation to this work.

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