Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 5;382(3):29.
doi: 10.1007/s41061-024-00474-9.

A Review on Recent Development of Phenothiazine-Based Chromogenic and Fluorogenic Sensors for the Detection of Cations, Anions, and Neutral Analytes

Mohan Ilakiyalakshmi  1 , Kumudhavalli Dhanasekaran  1 , Ayyakannu Arumugam Napoleon  2
Affiliations
Review

A Review on Recent Development of Phenothiazine-Based Chromogenic and Fluorogenic Sensors for the Detection of Cations, Anions, and Neutral Analytes

Mohan Ilakiyalakshmi et al. Top Curr Chem (Cham). .

Abstract

This review provides an in-depth examination of recent progress in the development of chemosensors, with a particular emphasis on colorimetric and fluorescent probes. It systematically explores various sensing mechanisms, including metal-to-ligand charge transfer (MLCT), ligand-to-metal charge transfer (LMCT), photoinduced electron transfer (PET), intramolecular charge transfer (ICT), and fluorescence resonance energy transfer (FRET), and elucidates the mechanism of action for cation and anion chemosensors. Special attention is given to phenothiazine-based fluorescence probes, highlighting their exceptional sensitivity and rapid detection abilities for a broad spectrum of analytes, including cations, anions, and small molecules. Phenothiazine chemosensors have emerged as versatile tools widely employed in a multitude of applications, spanning environmental and biomedical fields. Furthermore, it addresses existing challenges and offers insights into future research directions, aiming to facilitate the continued advancement of phenothiazine-based fluorescent probes.

Keywords: Anions; Cations; Chemosensors; Fluorescent probe; Mechanism; Phenothiazine.

PubMed Disclaimer

References

    1. Adeva-Andany MM, Carneiro-Freire N, Donapetry-García C et al (2014) The importance of the ionic product for water to understand the physiology of the acid-base balance in humans. Biomed Res Int. https://doi.org/10.1155/2014/695281 - DOI - PubMed - PMC
    1. He F, Tang Y, Wang S et al (2005) Fluorescent amplifying recognition for DNA G-quadruplex folding with a cationic conjugated polymer: a platform for homogeneous potassium detection. J Am Chem Soc 127:12343–12346. https://doi.org/10.1021/ja051507i - DOI - PubMed
    1. Lodoso-Torrecilla I, Klein Gunnewiek R, Grosfeld EC et al (2020) Bioinorganic supplementation of calcium phosphate-based bone substitutes to improve: in vivo performance: a systematic review and meta-analysis of animal studies. Biomater Sci 8:4792–4809. https://doi.org/10.1039/d0bm00599a - DOI - PubMed
    1. Chan WC, Ng MP, Ang CW et al (2023) From lab to life: safe and efficient optical based dual-mode chemosensor for the detection of aluminium(III) and copper(II) ions. Inorganica Chim Acta 557:121703. https://doi.org/10.1016/j.ica.2023.121703 - DOI
    1. Dathees TJ, Makarios Paul SP, Sanmugam A et al (2024) Naphthalene derived Schiff base as a reversible fluorogenic chemosensor for aluminium ions detection. Spectrochim Acta Part A Mol Biomol Spectrosc 308:123732. https://doi.org/10.1016/j.saa.2023.123732 - DOI