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. 2024 Sep 3;13(1):44.
doi: 10.1186/s40035-024-00439-4.

A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer's disease

Kenji Tagai #  1   2 , Harutsugu Tatebe #  1 , Sayo Matsuura  1 , Zhang Hong  1 , Naomi Kokubo  1 , Kiwamu Matsuoka  1 , Hironobu Endo  1 , Asaka Oyama  1 , Kosei Hirata  1 , Hitoshi Shinotoh  1 , Yuko Kataoka  1 , Hideki Matsumoto  1   3 , Masaki Oya  1 , Shin Kurose  1   4 , Keisuke Takahata  1   4 , Masanori Ichihashi  1 , Manabu Kubota  1 , Chie Seki  1 , Hitoshi Shimada  1   5 , Yuhei Takado  1 , Kazunori Kawamura  1 , Ming-Rong Zhang  1 , Yoshiyuki Soeda  6 , Akihiko Takashima  6 , Makoto Higuchi  1 , Takahiko Tokuda  7
Affiliations

A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer's disease

Kenji Tagai et al. Transl Neurodegener. .
No abstract available

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Conflict of interest statement

Hitoshi Shimada, Ming-Rong Zhang, and Makoto Higuchi hold patents on compounds related to the present report (JP 5422782/EP 12 884 742.3/CA2894994/HK1208672).

Figures

Fig. 1
Fig. 1
Correlations of plasma mid-p-tau or N-p-tau level with tau or amyloid PET in the subjects with AD continuum. a The correlation between plasma mid-p-tau181 level and 18F-florzorotau tau PET is depicted through its topographical representation (P < 0.05, FWE-corrected). b, c Scatter plots of the correlation between plasma mid-p-tau181 level and tau PET tracer accumulation in each ROI. Pearson's correlation analysis was employed to calculate the r and P values. Statistical significance was established at P < 0.0125, corrected for multiple comparisons using the Bonferroni method. Regression analysis, indicated by a straight or curved line, depicts the preferred model, with its goodness of fit quantified using the R2 value. d Topographical representation of the correlation between plasma N-p-tau181 level and tau PET (P < 0.05, uncorrected). e, f Scatter plots of the correlation between plasma N-p-tau181 level and tau PET tracer accumulation in each ROI. The procedure for the correlation analysis was the same as that in b and c. g Topographical representation of the correlations of each plasma p-tau181 assay with amyloid- (left column) and tau- (right column) PET in the CN and AD continuum cohort (P < 0.05, FWE-corrected). h Bar graphs illustrating beta coefficient values of amyloid and tau PET in multiple liner regression analysis with each p-tau assay. *P < 0.05, **P < 0.005, ****P < 0.0005. P-values were corrected for multiple comparisons using Bonferonni correction with the number of explanatory variables
See this image and copyright information in PMC

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