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. 2024 Dec;110(4):116518.
doi: 10.1016/j.diagmicrobio.2024.116518. Epub 2024 Sep 2.

Delafloxacin, an alternative treatment for levofloxacin-resistant staphylococci in osteoarticular infections: To use or not to use?

Caroline Loïez  1 , Audrey Charlet  2 , Fanny Lemonnier  3 , Henri Migaud  4 , Éric Senneville  5 , Claire Duployez  2 , Frédéric Wallet  3
Affiliations

Delafloxacin, an alternative treatment for levofloxacin-resistant staphylococci in osteoarticular infections: To use or not to use?

Caroline Loïez et al. Diagn Microbiol Infect Dis. 2024 Dec.

Abstract

Susceptibility of delafloxacin on 199 osteoarticular levofloxacin-resistant staphylococci strains was reported in 49% and 1% using SSTI S. aureus breakpoint (0.25 mg/L) and general S. aureus breakpoint (0.016 mg/L) respectively. Fifty percents levofloxacin-resistant staphylococci showed resistance to delafloxacin using CA-SFM/EUCAST recommendations. Microbiological societies should define new breakpoints especially for CoNS.

Keywords: Delafloxacin; Fluoroquinolones; Osteoarticular infections; Staphylococcus.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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