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Review
. 2025 Jun;29(3):2783-2797.
doi: 10.1007/s11030-024-10978-7. Epub 2024 Sep 6.

An overview: total synthesis of arborisidine, and arbornamine

Gitanjali Yadav  1   2 , Megha  1 , Sangeeta Yadav  3 , Ravi Tomar  4   5
Affiliations
Review

An overview: total synthesis of arborisidine, and arbornamine

Gitanjali Yadav et al. Mol Divers. 2025 Jun.

Abstract

Arborisidine and Arbornamine are two monoterpenoid indole alkaloids that were isolated from the Malayan Kopsia arborea plant. This review provides valuable information about the total and formal syntheses of these alkaloids. The synthesis strategies discussed in this review, such as Pictet-Spengler cyclization, chemo- and stereoselective oxidative cyclization, Michael/Mannich cascade process, and intramolecular N-alkylation, can be useful for developing new methods to synthesize these and other similar compounds.

Keywords: Alkaloids; Arborisidine; Arbornamine; Cyclization; Natural product; Total synthesis.

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Conflict of interest statement

Declarations. Conflict of interests: The authors declare no competing interests.

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