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. 2024 Dec;150(6):543-561.
doi: 10.1111/acps.13748. Epub 2024 Sep 7.

The impact of sex in the effectiveness of functional remediation in bipolar disorder

Collaborators, Affiliations

The impact of sex in the effectiveness of functional remediation in bipolar disorder

Maria Serra-Navarro et al. Acta Psychiatr Scand. 2024 Dec.

Abstract

Background: Functional recovery remains a core clinical objective for patients with bipolar disorder (BD). Sociodemographic, clinical, and neurocognitive variables are associated with long-term functional impairment, yet the impact of sex differences is unclear. Functional remediation (FR) is a validated intervention aimed at achieving functional recovery in BD. The present study assessed the effect of sex differences of FR on psychosocial functioning at post-treatment (6-months) and 12-month follow-up (FUP). To the best of our knowledge, this is the first study to explore the role of sex as a factor in the efficacy of FR.

Methods: 157 participants with BD were randomly assigned to either FR (N = 77) or treatment as usual group (80). Clinical, sociodemographic, neuropsychological, and functional data were obtained using a comprehensive assessment battery. Sex differences were explored via a general linear model (GLM) for repeated measures to compare the effect of sex on the intervention over time (6 months and FUP).

Results: Results demonstrated that FR benefits both sexes, males (p = 0.001; d' = 0.88) and females (p = 0.04; d' = 0.57), at 6 months suggesting a generalized functional improvement. Conversely, at 12-month FUP sex differences were observed only in males (p = 0.005; d' = 0.68).

Conclusions: FR is a beneficial intervention for males and females after treatment, suggesting that there are no relevant distinct needs. Females may benefit from ongoing psychosocial functioning booster sessions after the intervention to maintain original improvements. Future research exploring sex differences could help to identify strategies to offer personalized FR intervention approaches in individuals with BD.

Keywords: bipolar disorder; functional remediation; psychosocial functioning; sex differences.

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References

REFERENCES

    1. Bonnin C d M, Valls E, Rosa AR, et al. Functional remediation improves bipolar disorder functioning with no effects on brain‐derived neurotrophic factor levels. Eur Neuropsychopharmacol. 2019;29(6):701‐710. doi:10.1016/j.euroneuro.2019.04.002
    1. Bonnín CM, Martínez‐Arán A, Torrent C, et al. Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long‐term, follow‐up study. J Affect Disord. 2010;121(1–2):156‐160. doi:10.1016/j.jad.2009.05.014
    1. Haro JM, Reed C, Gonzalez‐Pinto A, Novick D, Bertsch J, Vieta E. 2‐year course of bipolar disorder type I patients in outpatient care: factors associated with remission and functional recovery. Eur Neuropsychopharmacol. 2011;21(4):287‐293. doi:10.1016/j.euroneuro.2010.08.001
    1. Sanchez‐Moreno J, Bonnin CM, González‐Pinto A, et al. Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables. Acta Psychiatr Scand. 2018;138(2):145‐154. doi:10.1111/acps.12894
    1. Lomastro MJ, Valerio MP, Blasco MB, Tagni MF, Martino DJ. Predictors of high psychosocial functioning in bipolar disorder. J Nerv Ment Dis. 2020;208(11):904‐907. doi:10.1097/NMD.0000000000001224

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