Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May;31(5):402-411.
doi: 10.1007/s11655-024-3807-4. Epub 2024 Sep 7.

Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway

Lin-Zi Long  1 , Ling Tan  2 , Feng-Qin Xu  1 , Wen-Wen Yang  3 , Hong-Zheng Li  4 , Jian-Gang Liu  1 , Ke Wang  5 , Zhi-Ru Zhao  1 , Yue-Qi Wang  6 , Chao-Ju Wang  7 , Yi-Chao Wen  7 , Ming-Yan Huang  3 , Hua Qu  3 , Chang-Geng Fu  8 , Ke-Ji Chen  3   9
Affiliations

Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway

Lin-Zi Long et al. Chin J Integr Med. 2025 May.

Abstract

Objective: To assess the efficacy of Qingda Granule (QDG) in ameliorating hypertension-induced cardiac damage and investigate the underlying mechanisms involved.

Methods: Twenty spontaneously hypertensive rats (SHRs) were used to develope a hypertension-induced cardiac damage model. Another 10 Wistar Kyoto (WKY) rats were used as normotension group. Rats were administrated intragastrically QDG [0.9 g/(kg•d)] or an equivalent volume of pure water for 8 weeks. Blood pressure, histopathological changes, cardiac function, levels of oxidative stress and inflammatory response markers were measured. Furthermore, to gain insights into the potential mechanisms underlying the protective effects of QDG against hypertension-induced cardiac injury, a network pharmacology study was conducted. Predicted results were validated by Western blot, radioimmunoassay immunohistochemistry and quantitative polymerase chain reaction, respectively.

Results: The administration of QDG resulted in a significant decrease in blood pressure levels in SHRs (P<0.01). Histological examinations, including hematoxylin-eosin staining and Masson trichrome staining revealed that QDG effectively attenuated hypertension-induced cardiac damage. Furthermore, echocardiography demonstrated that QDG improved hypertension-associated cardiac dysfunction. Enzyme-linked immunosorbent assay and colorimetric method indicated that QDG significantly reduced oxidative stress and inflammatory response levels in both myocardial tissue and serum (P<0.01).

Conclusions: Both network pharmacology and experimental investigations confirmed that QDG exerted its beneficial effects in decreasing hypertension-induced cardiac damage by regulating the angiotensin converting enzyme (ACE)/angiotensin II (Ang II)/Ang II receptor type 1 axis and ACE/Ang II/Ang II receptor type 2 axis.

Keywords: Qingda Granule; blood pressure; cardiac damage; hypertension; renin-angiotensin system.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest. None declared.

Similar articles

See all similar articles

Cited by

References

    1. Lewington S, Lacey B, Clarke R, Guo Y, Kong XL, Yang L, et al. The burden of hypertension and associated risk for cardiovascular mortality in China. JAMA Intern Med 2016;176:524–532. - DOI - PubMed
    1. Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, et al. Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiol Rev 2018;98:1627–1738. - DOI - PubMed - PMC
    1. Liu W, Lin S, Cai Q, Zhang L, Shen A, Chen Y, et al. Qingxuan Jiangya Decoction mitigates renal interstitial fibrosis in spontaneously hypertensive rats by regulating transforming growth factor-α 1/Smad signaling pathway. Evid Based Complement Alternat Med 2017;2017:1576328. - DOI - PubMed - PMC
    1. Long LZ, Chu JF, Qu H, Yang QN, Lu Y, Fu CG, et al. Effects of Qingda Granule on patients with grade 1 hypertension at low-medium risk: study protocol for a randomized, controlled, double-blind clinical trial. Trials 2023;24:1–7. - DOI - PubMed - PMC
    1. Huang Y, Wu X, Wu M, Chu J, Yu N, Shen A, et al. Antihypertensive and vasodilatory effects of Qingda Granules by suppression of calcium influx and the AKT pathway. J Cardiovasc Pharmacol 2019;74:549–557. - DOI - PubMed

Substances

LinkOut - more resources