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Review
. 2024 Sep 7;19(1):143.
doi: 10.1186/s11671-024-04086-6.

Enhanced drug delivery with nanocarriers: a comprehensive review of recent advances in breast cancer detection and treatment

Ruby Dhiman  1   2 , Nancy Bazad  1 , Riya Mukherjee  3 , Himanshu  3 , Gunjan  3 , Elcio Leal  4 , Saheem Ahmad  5 , Kirtanjot Kaur  6 , V Samuel Raj  1 , Chung-Ming Chang  7   8   9 , Ramendra Pati Pandey  10
Affiliations
Review

Enhanced drug delivery with nanocarriers: a comprehensive review of recent advances in breast cancer detection and treatment

Ruby Dhiman et al. Discov Nano. .

Abstract

Breast cancer (BC) remains a leading cause of morbidity and mortality among women worldwide, with triple-negative breast cancer (TNBC) posing significant treatment challenges due to its aggressive phenotype and resistance to conventional therapies. Recent advancements in nanocarrier technology offer promising solutions for enhancing drug delivery, improving bioavailability, and increasing drug accumulation at tumor sites through targeted approaches. This review delves into the latest innovations in BC detection and treatment, highlighting the role of nanocarriers like polymeric micelles, liposomes, and magnetic nanoparticles in overcoming the limitations of traditional therapies. Additionally, the manuscript discusses the integration of cutting-edge diagnostic tools, such as multiplex PCR-Nested Next-Generation Sequencing (mPCR-NGS) and blood-based biomarkers, which are revolutionizing early detection and molecular profiling of BC. The convergence of these technologies not only enhances therapeutic outcomes but also paves the way for personalized medicine in BC management. This comprehensive review underscores the potential of nanocarriers in transforming BC treatment and emphasizes the critical importance of early detection in improving patient prognosis.

Keywords: Breast cancer; Diagnostic; Nanocarriers; Tumor location.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The stages of breast cancer
Fig. 2
Fig. 2
Symptoms for prognosis and small molecule drug delivery process in Triple-negative breast cancer
Fig. 3
Fig. 3
Classification of nanocarriers
See this image and copyright information in PMC

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