Lack of effect of chloramphenicol on monoamine, diamine and plasma amine oxidase activities

Abstract

Chloramphenicol treatment in rabbits (60 mg/kg i.m. for 5 days) did not affect significantly (P greater than 0.1) the activities of monoamine oxidase (MAO) or diamine oxidase (DAO) in liver, heart or brain. Plasma amine oxidase (PAO) was not significantly inhibited (P greater than 0.1) in goats treated with chloramphenicol (60 mg/kg i.m. for 5 days). Chloramphenicol (2 X 10(-3) mol/l) preincubated with rabbit hepatic MAO had no significant effect (P greater than 0.1) on the enzyme activity.