Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 9;24(1):521.
doi: 10.1186/s12884-024-06682-x.

High-risk factors for massive haemorrhage in medical abortion patients with missed miscarriage

Yuru Tan #  1   2 , Sen Li #  1   2 , Hong Xu #  3   4 , Shuying Wang #  5   6
Affiliations

High-risk factors for massive haemorrhage in medical abortion patients with missed miscarriage

Yuru Tan et al. BMC Pregnancy Childbirth. .

Abstract

Background: Recently, the incidence of missed miscarriage has gradually increased, and medical abortion is a common method to terminate a pregnancy. In the process of medical abortion, massive vaginal bleeding takes place, leading to emergency surgical haemostasis. Emergency surgery may produce infection and organ damage. Our study aimed to investigate the high-risk factors for massive haemorrhage during a medical abortion.

Methods: A total of 1062 missed miscarriage patients who underwent medical abortion participated in this retrospective study. According to the amount of bleeding, the patients were divided into a massive haemorrhage group and a control group. By comparing the general conditions of the two groups, such as fertility history, uterine surgery history, uterine fibroids, etc., the high-risk factors for massive haemorrhage during medical abortion were identified.

Results: Relative to the control group, the massive haemorrhage group exhibited a higher proportion of patients with a previous artificial abortion (51.9% vs. 38.1%, P = 0.001). Additionally, the massive haemorrhage group had a lower percentage of first-time pregnant women (32.1% vs. 40.4%) and a higher proportion of women with shorter pregnancy intervals (44.9% vs. 33.1%, P = 0.03). Furthermore, there were notable differences between the two groups regarding maximum fibroid size, the duration of amenorrhea, and gestational week (P < 0.05).

Conclusion: In this study, we determined that a history of artificial abortion and an amenorrhea duration of > 11 weeks represented high-risk factors for massive vaginal bleeding during medical abortion in missed miscarriage patients.

Keywords: Emergency surgery; Massive haemorrhage; Medical abortion; Missed miscarriage.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the study workflow
Fig. 2
Fig. 2
Forest plot depicting univariate analysis results
See this image and copyright information in PMC

References

    1. 2019 exceptional surveillance of ectopic pregnancy. And miscarriage: diagnosis and initial management (NICE guideline NG126) [Internet]. London: National Institute for Health and Care Excellence (NICE); 2019. Nov 15. - PubMed
    1. Hu H, Yang H, Yin Z, et al. [Chromosome examination of missed abortion patients]. Zhonghua Yi Xue Za Zhi. 2015;95(35):2837–40. 10.3760/cma.j.issn.0376-2491.2015.35.006. 10.3760/cma.j.issn.0376-2491.2015.35.006 - DOI - PubMed
    1. Zhu D, Wei X, Zhou X-Y, et al. Chromosomal abnormalities in recurrent pregnancy loss and its association with clinical characteristics. J Assist Reprod Genet. 2023;40(7):1713–20. 10.1007/s10815-023-02816-w. 10.1007/s10815-023-02816-w - DOI - PMC - PubMed
    1. Gong G, Yin C, Huang Y, et al. A survey of influencing factors of missed abortion during the two-child peak period. J Obstet Gynaecol. 2021;41(6):977–80. 10.1080/01443615.2020.1821616. 10.1080/01443615.2020.1821616 - DOI - PubMed
    1. Ali S, Majid S, Niamat Ali M, et al. Evaluation of T cell cytokines and their role in recurrent miscarriage. Int Immunopharmacol. 2020;82:106347. 10.1016/j.intimp.2020.106347. 10.1016/j.intimp.2020.106347 - DOI - PubMed

LinkOut - more resources