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. 2024 Sep 2:16:325-335.
doi: 10.2147/HIV.S477809. eCollection 2024.

Prevalence, Awareness, and Factors Associated with Hypertension Among People Living with HIV in Eastern Uganda. A Multicentre Cross-Sectional Study

Andrew Marvin Kanyike #  1   2 , Ashley Winfred Nakawuki  3 , Gabriel Madut Akech  1 , Raymond Bernard Kihumuro  4 , Timothy Mwanje Kintu  5 , Racheal Nalunkuma  2 , Rachael Mukisa Nakandi  2 , Joshua Mugabi  1 , Nicholas Twijukye  1 , Denis Bwayo  1 , Richard Katuramu #  1
Affiliations

Prevalence, Awareness, and Factors Associated with Hypertension Among People Living with HIV in Eastern Uganda. A Multicentre Cross-Sectional Study

Andrew Marvin Kanyike et al. HIV AIDS (Auckl). .

Abstract

Introduction: Despite advancements in Antiretroviral Therapy (ART), people living with HIV (PLHIV) face increasing risks of HTN, leading to significant morbidity and premature mortality, undermining the hard-earned gains of fighting HIV. The prevalence of hypertension among HIV patients and associated risk factors has not been extensively studied in the rural parts of Uganda.

Objective: We assessed the prevalence, awareness, and factors associated with hypertension among PLHIV at two health facilities in Eastern Uganda.

Methods: A cross-sectional study was conducted at Mbale Regional Referral Hospital and Bugobero Health Center IV HIV clinics from May to July 2023. We recruited patients with HIV above the age of 18 years and willing to consent. Participants were interviewed using a structured questionnaire adapted from the WHO STEPwise approach to noncommunicable disease risk factor surveillance (STEPS) and the AIDS Clinical Trials Group. Anthropometric measurements and blood pressure were taken. Bivariate and multivariable logistic regression were performed. A P value <0.2 in the bivariate analysis was transferred to the multivariable logistic regression model. A P value < 0.05 was statistically significant.

Results: The study surveyed 400 PLHIV with a mean age of 46.5 (SD: 12.4) years; most were female (n=261, 65.3%). Hypertension prevalence was at 37.5%, with 20.5% in stage 2 and 68% ((n=102) of hypertensive participants were unaware. Hypertension was associated with age ≥50 years (aOR: 2.11, 95% CI: 1.33-3.37, p = 0.002), a suppressed viral load (aOR: 3.71, 95% CI: 1.02-5.13, p = 0.046) and BMI ≥25 Kg/m2 (aOR: 1.64, 95% CI: 1.01-2.66, p = 0.044).

Conclusion: Hypertension is a significant burden among PLHIV in Eastern Uganda, influenced by HIV and lifestyle-related risk factors. Improved screening and diagnosis are needed with close monitoring for patients with viral load suppression due to the possible negative effects of ART on blood pressure.

Keywords: antiretroviral therapy; body mass index; human immunodeficiency syndrome; hypertension.

Plain language summary

This study explored the prevalence, awareness, and risk factors linked to high blood pressure among people living with HIV (PLHIV) at two health facilities in Eastern Uganda. We found that 37.5% of the participants had high blood pressure, yet the majority (68%) were unaware of their condition. We identified older age ≥50 years, a higher body mass index (BMI) ≥ 25 kg/m2, and having a suppressed viral load as significant risk factors for high blood pressure among PLHIV. These results reveal the urgent need for improved health strategies that integrate the management of HIV and hypertension and preventive care to enhance the overall health outcomes for PLHIV in rural areas.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Percentage awareness of hypertension among hypertensive patients with HIV (N=150).
Figure 2
Figure 2
Distribution of Systolic and Diastolic Blood Pressure Values (A). Comparison by sex of SBP (B) and DBP values (C). No significant difference was observed between the sexes. An Independent t-test was performed.
Figure 3
Figure 3
Categorization of hypertension according to stages and Age.
See this image and copyright information in PMC

References

    1. Joint United Nations Programme on HIV/AIDS. Latest global and regional HIV statistics on the status of the AIDS epidemic - Fact sheet 2024; 2024. Availabe from: https://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_.... Accessed August 29, 2024.
    1. Kazooba P, Kasamba I, Mayanja BN, et al.. Cardiometabolic risk among hiv-positive Ugandan adults: prevalence, predictors and effect of long-term antiretroviral therapy. Pan Afr Med J. 2017:27. doi: 10.11604/pamj.2017.27.40.9840 - DOI - PMC - PubMed
    1. Haldane V, Legido-Quigley H, Chuah FLH, et al. Integrating cardiovascular diseases, hypertension, and diabetes with HIV services: a systematic review. AIDS Care. 2018;30(1):103–115. doi: 10.1080/09540121.2017.1344350 - DOI - PubMed
    1. Wang H, Wolock TM, Carter A, et al. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015. Lancet HIV. 2016;3(8):e361–e387. doi: 10.1016/S2352-3018(16)30087-X - DOI - PMC - PubMed
    1. Nüesch R, Wang Q, Elzi L, et al. Risk of Cardiovascular Events and Blood Pressure Control in Hypertensive HIV-Infected Patients. JAIDS J Acquir Immune Defic Syndr. 2013;62(4):396–404. doi: 10.1097/QAI.0b013e3182847cd0 - DOI - PubMed

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