Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 4:17:3325-3333.
doi: 10.2147/DMSO.S478287. eCollection 2024.

Role of Triglyceride-Glucose Index in Type 2 Diabetes Mellitus and Its Complications

Ying Pan  1 , Mengjie Zhao  1 , Tiantian Song  2 , Jia Tang  2 , Ming Kuang  2 , Hongying Liu #  2 , Shao Zhong #  3
Affiliations
Review

Role of Triglyceride-Glucose Index in Type 2 Diabetes Mellitus and Its Complications

Ying Pan et al. Diabetes Metab Syndr Obes. .

Abstract

Insulin resistance (IR) is the major mechanism in the pathogenesis of type 2 diabetes mellitus (T2DM). Early identification of IR is of great significance for preventing the onset of T2DM and delaying the progression of the disease. Previous studies have shown that triglyceride-glucose (TyG) index can be used as an effective surrogate marker for IR. There is a significant correlation between TyG index and T2DM and its common complications. In addition, the predictive efficacy of TyG index is better than that of other IR surrogate indicators. TyG index may not only become an important marker to identify people at high risk of T2DM and its complications, but is also expected to become a strong predictor of the prognosis of these diseases. However, there are still some challenges in the widespread application of TyG index in clinical practice. In the future, more high-quality studies are needed to clarify the assessment methods of TyG index for the prognosis of T2DM and its complications. Further investigations of the relationship between TyG index and T2DM and its complications will be expected to provide new ideas and methods for the prevention and treatment of T2DM and its complications.

Keywords: complication; insulin resistance; triglyceride-glucose index; type 2 diabetes mellitus.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest related to this review article.

Figures

Figure 1
Figure 1
Suggested Directions for Future Research.
See this image and copyright information in PMC

References

    1. Sun H, Saeedi P, Karuranga S, et al. IDF diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabet Res Clin Pract. 2022;183:109119. doi:10.1016/j.diabres.2021.109119 - DOI - PMC - PubMed
    1. American Diabetes Association Professional Practice Committee. 2 Diagnosis and classification of diabetes: standards of care in diabetes-2024. Diabetes Care. 2024;47(Suppl 1):S20–S42. doi:10.2337/dc24-S002 - DOI - PMC - PubMed
    1. Minh HV, Tien HA, Sinh CT, et al. Assessment of preferred methods to measure insulin resistance in Asian patients with hypertension. J Clin Hypertens. 2021;23(3):529–537. doi:10.1111/jch.14155 - DOI - PMC - PubMed
    1. Ramdas Nayak VK, Satheesh P, Shenoy MT, Kalra S. Triglyceride glucose (TyG) Index: a surrogate biomarker of insulin resistance. J Pak Med Assoc. 2022;72(5):986–988. doi:10.47391/JPMA.22-63 - DOI - PubMed
    1. Er LK, Wu S, Chou HH, et al. Triglyceride glucose-body mass index is a simple and clinically useful surrogate marker for insulin resistance in nondiabetic individuals. PLoS One. 2016;11(3):e0149731. doi:10.1371/journal.pone.0149731 - DOI - PMC - PubMed

LinkOut - more resources