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Case Reports
. 2024 Aug 16;19(11):4917-4920.
doi: 10.1016/j.radcr.2024.07.140. eCollection 2024 Nov.

Lymphoepithelial carcinoma of the submandibular gland in a Japanese male: A case report

Takao Yoshida  1 , Yoshiki Watanabe  1 , Yasuyuki Hiratsuka  1
Affiliations
Case Reports

Lymphoepithelial carcinoma of the submandibular gland in a Japanese male: A case report

Takao Yoshida et al. Radiol Case Rep. .

Abstract

Lymphoepithelial carcinoma of the submandibular gland is an extremely rare condition; therefore, no clear clinical features or established treatment is available for this. A 58-year-old Japanese man who came to our hospital with the complaint of swelling of the left submandibular region was diagnosed with stage IVa, T4aN2bM0 lymphoepithelial carcinoma of the submandibular gland. We also examined the relationship between the tumor and Epstein-Barr virus by Epstein-Barr virus encoded ribonucleoprotein in situ hybridization. The patient was treated by performing segmental mandibulectomy, neck dissection, mandibular reconstruction, and adjuvant chemoradiotherapy. After 2 years of treatment, good progress has been observed in the patient without any signs of recurrence. Here, we have reported the treatment of a patient with lymphoepithelial carcinoma of the submandibular gland using literature review.

Keywords: Epstein–Barr virus; Lymphoepithelial carcinoma; Salivary cancer; Segmental mandibulectomy; Submandibular gland.

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Figures

Fig 1:
Fig. 1
Contrast-enhanced magnetic resonance imaging (MRI) during initial examination. A tumor with unclear border surrounding the inferior border of the left mandible (*), with several enlarged lymph nodes in the left mandibular region (arrow head), and contrast-enhancement in the mandibular bone (arrow) were observed.
Fig 2:
Fig. 2
Pathological findings of the submandibular tumor. (A) Haematoxylin and eosin staining (×400), (B) EBER-ISH (×100). (A) Irregular and uneven alveolar invasion of a poorly differentiated tumor was observed extending in insular form with lymphoid stroma. (B) The majority of tumor cells exhibited EBER-ISH signal.
Fig 3:
Fig. 3
Surgical outcomes. Osteotomy of the mandible was performed between the second and third lower left teeth with the ramus of mandible, which was resected en bloc with the tumor. The mandible defect site was reconstructed using a free fibular flap and titanium plate (arrow head).
See this image and copyright information in PMC

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