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. 2024 Sep 3:17:3825-3837.
doi: 10.2147/IDR.S475073. eCollection 2024.

Prognostic Factors That Affect Mortality Patients with Acinetobacter baumannii Bloodstream Infection

Chunrong Huang #  1   2 , Yulian Gao #  1   2 , Hongxia Lin #  1   2   3 , Qinmei Fan #  4 , Ling Chen  1   2 , Yun Feng  1   2
Affiliations

Prognostic Factors That Affect Mortality Patients with Acinetobacter baumannii Bloodstream Infection

Chunrong Huang et al. Infect Drug Resist. .

Abstract

Background: To evaluate the clinical features of patients with Acinetobacter baumannii bloodstream infection (BSI).

Methods: Totally 200 inpatients with Acinetobacter baumannii BSI were included, clinical features of Acinetobacter baumannii BSI inpatients between 90-day survival and 90-day mortality groups, between 30-day survival and 30-day mortality groups, between patients infected with multidrug-resistant (MDR group) and sensitive Acinetobacter baumannii (sensitive group) were analyzed. The prognostic factors of 90-day mortality were analyzed by univariate logistic regression and multivariate logistic regression. The survival curve in bloodstream infectious patients with multidrug-resistant (MDR group) and sensitive Acinetobacter baumannii (sensitive group) was analyzed by Kaplan-Meier analysis.

Results: The 90-day mortality patients had significantly higher carbapenem-resistant bacterial infection and critical care unit (ICU) admission. The 90-day and 30-day mortality groups showed higher C-reactive protein (CRP) and serum creatinine (Scr) levels and lower red blood cells (RBC) and albumin (ALB) levels than their survival counterparts, respectively. Critical surgery, ICU admission and delayed antibiotic treatment were independently prognostic risk predictors for 90-day mortality in Acinetobacter baumannii BSI patients, while critical surgery and diabetes were independently prognostic risk predictors for 90-day mortality in carbapenem-resistant Acinetobacter baumannii BSI patients. Compared with sensitive group, MDR group showed significantly longer ICU and whole hospital stay, lower levels of lymphocytes, RBC, hemoglobin, lactate dehydrogenase and ALB, higher frequency of infection originating from the skin and skin structure. Moreover, patients in the MDR group had a significantly worse overall survival than the sensitive group.

Conclusion: We identified the prognostic factors of Acinetobacter baumannii BSI and carbapenem-resistant Acinetobacter baumannii BSI patients. Critical surgery, ICU admission, delayed antibiotic treatment or diabetes were significantly associated with the mortality of those patients. Moreover, aggressive measures to control MDR Acinetobacter baumannii could lead to improved outcomes.

Keywords: Acinetobacter baumannii; bloodstream infection; mortality; multidrug-resistance; prognostic predictors.

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Conflict of interest statement

There are no competing interests among these authors.

Figures

None
Graphical abstract
Figure 1
Figure 1
Kaplan–Meier curves for the OS of patients in the MDR group and sensitive group.
See this image and copyright information in PMC

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