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Randomized Controlled Trial
. 2024 Sep 4:18:3951-3958.
doi: 10.2147/DDDT.S475176. eCollection 2024.

Efficacy and Safety of General Anesthesia Induction with Ciprofol in Hip Fracture Surgery of Elderly Patients: A Randomized Controlled Trial

Yan-Fei Lu #  1 , Ji-Min Wu #  2 , Hai-Yan Lan  2 , Qiao-Min Xu  2 , Shu-Qi Shi  2 , Gong-Chen Duan  2
Affiliations
Randomized Controlled Trial

Efficacy and Safety of General Anesthesia Induction with Ciprofol in Hip Fracture Surgery of Elderly Patients: A Randomized Controlled Trial

Yan-Fei Lu et al. Drug Des Devel Ther. .

Abstract

Background: Ciprofol is a new intravenous sedative / anesthetic drug. In recent years, many clinical studies have also confirmed the sedative effect of ciprofol. However, more clinical research is still needed on its clinical application characteristics in special populations.

Objective: The aim of this study was to compare the clinical effects of ciprofol and propofol in general anesthesia induction of elderly patients.

Methods: 60 elderly (aged ≥ 75 years) patients underwent hip fracture surgery were randomly into two groups of a 1:1 ratio. Group C (ciprofol group): 0.3mg/kg ciprofol was infused. Group P (propofol group): 1.5mg/kg propofol was infused. The observation period was from the infusion of test drug to 5 min after endotracheal intubation. The primary outcomes included the incidence of severe hypotension and hypotension during the observation period. The secondary outcomes were as follows: the success rate of general anesthesia induction, the number of additional sedation, the time of loss of consciousness (LOC), Δ MAP, Δ HR, adverse events and the frequency of vasoactive drugs used.

Results: Finally, 60 subjects completed the study. Compared with Group P, the incidence of severe hypotension in Group C was lower (26.7% vs 53.3%, P = 0.035), the incidence of hypotension was also lower (36.7% vs 63.3%, P = 0.037), Δ MAP in Group C was significantly lower (31.4 ± 11.4 vs 39.6 ± 15.7, P = 0.025), the frequency of ephedrine used and the incidence of injection pain in Group C were also significantly lower.

Conclusion: Ciprofol showed similar efficacy to propofol when used for general anesthesia induction in elderly patients underwent hip fracture surgery and could maintain more stable blood pressure.

Keywords: Ciprofol; Hip fracture surgery; elderly; general anesthesia; hypotension.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of this study.
Figure 2
Figure 2
MAP changes during observation period. T0: baseline; T1: after successful induction; T2: before tracheal intubation; T3: 1 min after tracheal intubation; T4: 3 min after tracheal intubation; T5: 5 min after tracheal extubation. Data were presented as mean ± standard deviation. *P<0.05 compared with Group P.
Figure 3
Figure 3
HR changes during observation period. T0: baseline; T1: after successful induction; T2: before tracheal intubation; T3: 1 min after tracheal intubation; T4: 3 min after tracheal intubation; T5: 5 min after tracheal extubation. Data were presented as mean ± standard deviation.
See this image and copyright information in PMC

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