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Comparative Study
. 2024 Aug 23:15:1439326.
doi: 10.3389/fendo.2024.1439326. eCollection 2024.

Cross-sectional comparison of the association between three different insulin resistance surrogates and frailty: NHANES 1999-2018

Tianjie Lai  1 , Fenglei Guan  2 , Yunxian Chen  2 , Konghe Hu  1
Affiliations
Comparative Study

Cross-sectional comparison of the association between three different insulin resistance surrogates and frailty: NHANES 1999-2018

Tianjie Lai et al. Front Endocrinol (Lausanne). .

Abstract

Background: The correlation between various insulin resistance surrogates and frailty remains under investigation in the scientific community.

Methods: Data from NHANES (1999-2018) were used. We utilized weighted binary logistic regression, trend tests, RCS analysis, and subgroup analysis to comprehensively assess the link between METS-IR, HOMA-IR, and TyG, and frailty risk.

Results: The results revealed a significant positive association between high levels of METS-IR, HOMA-IR, and TyG with the risk of frailty in all models. Notably, in model 4, the highest quintile of METS-IR showed the strongest link (OR: 2.960, 95% CI: 2.219-3.949), with HOMA-IR (OR: 2.522, 95% CI: 1.927-3.301) following closely behind. Trend tests revealed a positive trend between METS-IR, HOMA-IR, and TyG with the risk of frailty (P for trend < 0.05). RCS analysis showed a linear relationship between METS-IR and the risk of frailty (P for nonlinearity > 0.05). In contrast, HOMA-IR and TyG exhibited a U-shaped nonlinear relationship (P for nonlinearity < 0.05).

Conclusion: The research identified a linear association between METS-IR and frailty risk, whereas HOMA-IR and TyG displayed a U-shaped, nonlinear relationship pattern with the risk of frailty. Among the varying levels examined, the linkage between METS-IR and frailty was most pronounced in the top quintile.

Keywords: HOMA-IR; METS-IR; NHANES; TyG; frailty; insulin resistance surrogates.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the participants’ selection.
Figure 2
Figure 2
Trend tests of association between different IR surrogates and frailty.
Figure 3
Figure 3
RCS analysis of the association between different IR surrogates and frailty.
Figure 4
Figure 4
Subgroup analysis of the relationship between different IR surrogates and frailty.
See this image and copyright information in PMC

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