Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 9;51(1):969.
doi: 10.1007/s11033-024-09897-5.

Cardioprotective effect of Vitamin D on cardiac hypertrophy through improvement of mitophagy and apoptosis in an experimental rat model of levothyroxine -induced hyperthyroidism

Farid Shokri #  1 , Khadijeh Ramezani-Aliakbari #  2 , Mohammad Zarei  1   3 , Alireza Komaki  3   4 , Safoura Raoufi  1   3 , Hanieh Naddaf  5 , Fatemeh Ramezani-Aliakbari  6   7
Affiliations

Cardioprotective effect of Vitamin D on cardiac hypertrophy through improvement of mitophagy and apoptosis in an experimental rat model of levothyroxine -induced hyperthyroidism

Farid Shokri et al. Mol Biol Rep. .

Abstract

Background: Mitochondria are known to be involved in mediating the calorigenic effects of thyroid hormones. With an abundance of these hormones, alterations in energy metabolism and cellular respiration take place, leading to the development of cardiac hypertrophy. Vitamin D has recently gained attention due to its involvement in the regulation of mitochondrial function, demonstrating promising potential in preserving the integrity and functionality of the mitochondrial network. The present study aimed to investigate the therapeutic potential of Vitamin D on cardiac hypertrophy induced by hyperthyroidism, with a focus on the contributions of mitophagy and apoptosis as possible underlying molecular mechanisms.

Methods and results: The rats were divided into three groups: control; hyperthyroid; hyperthyroid + Vitamin D. Hyperthyroidism was induced by Levothyroxine administration for four weeks. Serum thyroid hormones levels, myocardial damage markers, cardiac hypertrophy indices, and histological examination were assessed. The assessment of Malondialdehyde (MDA) levels and the expression of the related genes were conducted using heart tissue samples. Vitamin D pretreatment exhibited a significant improvement in the hyperthyroidism-induced decline in markers indicative of myocardial damage, oxidative stress, and indices of cardiac hypertrophy. Vitamin D pretreatment also improved the downregulation observed in myocardial expression levels of genes involved in the regulation of mitophagy and apoptosis, including PTEN putative kinase 1 (PINK1), Mitofusin-2 (MFN2), Dynamin-related Protein 1 (DRP1), and B cell lymphoma-2 (Bcl-2), induced by hyperthyroidism.

Conclusions: These results suggest that supplementation with Vitamin D could be advantageous in preventing the progression of cardiac hypertrophy and myocardial damage.

Keywords: Apoptosis; Cardiac hypertrophy; Hyperthyroidism; Mitochondria; Mitophagy; Vitamin D.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Kanda V, Sathyamurthy P, Narayanan L (2016) Cardiovascular manifestations in hyperthyroidism. Int j res med sci 4(7):3032. https://doi.org/10.18203/2320-6012.ijrms20161992 - DOI
    1. Sheng CX, Zhang CJ, Li YZ, Sun YM (2020) Effect of β-casomorphin-7 on myocardial hypertrophy in hyperthyroidism-induced cardiomyopathy. Eur Rev Med Pharmacol Sci 24(11):6380–6389. https://doi.org/10.26355/eurrev_202006_21536 - DOI
    1. Ojamaa K (2010) Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy. Vascul Pharmacol 52(3–4):113–119. https://doi.org/10.1016/j.vph.2009.11.008 - DOI
    1. Khamis T, Alsemeh AE, Abdullah DM (2022) Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways. Sci Rep 12(1):1–13. https://doi.org/10.1038/s41598-022-18860-y - DOI
    1. Venediktova N, Solomadin I, Nikiforova A, Starinets V, Mironova G (2021) Functional state of Rat Heart Mitochondria in experimental hyperthyroidism. Int J Mol Sci 22(21):11744. https://doi.org/10.3390/ijms222111744 - DOI

MeSH terms

LinkOut - more resources