Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia

Tanxin Liu^{1

2}, Keren Xu^{1

2}, Anmol Pardeshi^{1

2}, Swe Swe Myint^{1

2}, Alice Y Kang³, Libby M Morimoto³, Michael R Lieber⁴, Joseph L Wiemels^{1

2}, Scott C Kogan⁵, Catherine Metayer³, Adam J de Smith^{6

7}

Affiliations

¹ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
² USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
³ School of Public Health, University of California Berkeley, Berkeley, CA, USA.
⁴ Departments of Pathology, Biochemistry, Molecular Microbiology & Immunology, and Section of Molecular & Computational Biology (Department of Biological Sciences), University of Southern California, Los Angeles, CA, USA.
⁵ Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
⁶ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. desmith@usc.edu.
⁷ USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. desmith@usc.edu.

Tanxin Liu et al. Leukemia. 2024 Nov.

. 2024 Nov;38(11):2492-2496.

doi: 10.1038/s41375-024-02407-3. Epub 2024 Sep 9.

¹ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
² USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
³ School of Public Health, University of California Berkeley, Berkeley, CA, USA.
⁴ Departments of Pathology, Biochemistry, Molecular Microbiology & Immunology, and Section of Molecular & Computational Biology (Department of Biological Sciences), University of Southern California, Los Angeles, CA, USA.
⁵ Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
⁶ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. desmith@usc.edu.
⁷ USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. desmith@usc.edu.

No abstract available

Conflict of interest statement

The authors declare no competing interests.

Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia.
de Smith A, Liu T, Xu K, Pardeshi A, Myint SS, Kang A, Morimoto L, Lieber M, Wiemels J, Kogan S, Metayer C. de Smith A, et al. Res Sq [Preprint]. 2024 Jun 20:rs.3.rs-4510345. doi: 10.21203/rs.3.rs-4510345/v1. Res Sq. 2024. Update in: Leukemia. 2024 Nov;38(11):2492-2496. doi: 10.1038/s41375-024-02407-3. PMID: 38946984 Free PMC article. Updated. Preprint.

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