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. 2024 Sep 9;14(1):21021.
doi: 10.1038/s41598-024-71924-z.

The relationship between brain structure volumes, depressive symptoms and body composition in obese/overweight and normal-/underweight women

Lidia Łapińska  1 , Aleksandra Szum-Jakubowska  2 , Anna Krentowska  3 , Mikołaj Pawlak  4   5 , Marcin Hładuński  6 , Napoleon Waszkiewicz  7 , Monika Karczewska-Kupczewska  3 , Karol Kamiński  2 , Irina Kowalska  3
Affiliations

The relationship between brain structure volumes, depressive symptoms and body composition in obese/overweight and normal-/underweight women

Lidia Łapińska et al. Sci Rep. .

Abstract

Depressive symptoms are highly prevalent and heterogeneous in women. Different brain structures might be associated with depressive symptoms and body composition in women with obesity/overweight and normal-/underweight, although the data is limited. The analysis included 265 women from Bialystok PLUS population study, untreated with antidepressive or antipsychotic medications. The subjects underwent brain magnetic resonance imaging and body composition analysis. Beck Depression Inventory (BDI) score was inversely associated with nucleus accumbens volume (β = -0.217, p = 0.008) in women with BMI ≥ 25 kg/m2, but with insula volume (β = -0.147, p = 0.027) in women with BMI < 25 kg/m2 after adjustment for age and estimated intracranial volume (eTIV). In women with BMI ≥ 25 kg/m2, nucleus accumbens volume was inversely associated with the percentage of visceral fat and BDI score (β = -0.236, p = 0.012, β = -0.192, p = 0.017) after adjustment for age and eTIV. In women with BMI < 25 kg/m2, insula volume was positively associated with total fat-free mass and negatively with the BDI score (β = 0.142, p = 0.030, β = -0.137, p = 0.037) after adjustment for age and eTIV. Depressive symptoms might be associated with nucleus accumbens volume in overweight/obese women, while in normal-/ underweight women-with alterations in insula volume.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Selection of the study groups from the population cohort study.
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