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. 2024 Oct;205(4):1599-1604.
doi: 10.1111/bjh.19740. Epub 2024 Sep 10.

Major reduction in occurrence of anti-c and anti-E in pregnancy after more than 10 years of preventive matched transfusion with most benefit for c-matching

Jessie S Luken  1 , Claudia C Folman  1 , Johan H Meekers  2 , Michael V Lukens  2 , C Ellen van der Schoot  3   4 , Masja de Haas  1   4   5
Affiliations

Major reduction in occurrence of anti-c and anti-E in pregnancy after more than 10 years of preventive matched transfusion with most benefit for c-matching

Jessie S Luken et al. Br J Haematol. 2024 Oct.

Abstract

Extension with cE-matching of the transfusion policy for women under 45 years to prevent alloimmunization and hemolytic disease of the foetus and newborn (HDFN) was evaluated. After implementation of cEK-matching, anti-c occurrence decreased from 46.8 to 30.4 per 100 000 pregnancies (RR 0.65, 95% CI 0.54-0.79), while anti-E occurrence decreased from 122.1 to 89.9 per 100 000 pregnancies (RR 0.74, 95% CI 0.66-0.84). The c-negative women showed a higher anti-E occurrence before cEK-matching and a more pronounced decline with the new policy. This indicates that cEK-matched transfusion effectively reduces alloimmunization, and that a cK-matched approach could prevent most transfusion-related alloimmunization and HDFN.

Keywords: hemolytic disease of the fetus and newborn; immunohaematology; pregnancy; red cell antigens; transfusion.

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References

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