Proposal for a reappraisal of the current classification of so-called "somatic-type" malignancies arising in germ cell tumours

Andres M Acosta¹, Daniel M Berney², João Lobo^{3

4

5}, Muhammad T Idrees¹, Thomas M Ulbright¹

Affiliations

¹ Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
² Centre for Cancer Biomarkers & Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, UK.
³ Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center Raquel Seruca (P.CCC), Porto, Portugal.
⁴ Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca, Porto, Portugal.
⁵ Department of Pathology and Molecular Immunology, ICBAS-School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal.

Editorial

Andres M Acosta et al. Histopathology. 2024 Nov.

. 2024 Nov;85(5):743-745.

doi: 10.1111/his.15288. Epub 2024 Sep 10.

Andres M Acosta¹, Daniel M Berney², João Lobo^{3

4

5}, Muhammad T Idrees¹, Thomas M Ulbright¹

¹ Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
² Centre for Cancer Biomarkers & Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, UK.
³ Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center Raquel Seruca (P.CCC), Porto, Portugal.
⁴ Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca, Porto, Portugal.
⁵ Department of Pathology and Molecular Immunology, ICBAS-School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal.

No abstract available

Keywords: germ cell tumour; somatic‐type malignancy; teratoma; testicular cancer; testis.

References

1. Magers MJ, Kao C‐S, Cole CD et al. “Somatic‐type” malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin. Am. J. Surg. Pathol. 2014; 38; 1396–1409.
1. Howitt BE, Magers MJ, Rice KR, Cole CD, Ulbright TM. Many postchemotherapy sarcomatous tumors in patients with testicular germ cell tumors are sarcomatoid yolk sac tumors: a study of 33 cases. Am. J. Surg. Pathol. 2015; 39; 251–259.
1. Bremmer F, Pongratanakul P, Skowron M et al. Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor‐related somatic‐type malignancies to identify the tissue‐of‐origin, mechanisms of therapy resistance, and druggable targets. Br. J. Cancer 2023; 129; 1580–1589.
1. Wyvekens N, Sholl LM, Yang Y et al. Molecular correlates of male germ cell tumors with overgrowth of components resembling somatic malignancies. Mod. Pathol. 2022; 35; 1966–1973.
1. Lobo J, Rodrigues Â, Henrique R et al. Morphological spectrum and molecular features of somatic malignant transformation in germ cell tumours. Histopathology 2022; 81; 84–98.