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. 2024 Sep 4:16:587-601.
doi: 10.2147/CLEP.S472553. eCollection 2024.

Burden of Gastrointestinal Tumors in Asian Countries, 1990-2021: An Analysis for the Global Burden of Disease Study 2021

Donglin Jiang  1 , Yangxue Wu  1 , Ling Liu  1 , Yajing Shen  1 , Tiandong Li  1 , Yin Lu  1 , Peng Wang  2 , Changqing Sun  2 , Kaijuan Wang  2 , Keyan Wang  3 , Hua Ye  1
Affiliations

Burden of Gastrointestinal Tumors in Asian Countries, 1990-2021: An Analysis for the Global Burden of Disease Study 2021

Donglin Jiang et al. Clin Epidemiol. .

Abstract

Background: Gastrointestinal tumors represent a significant component of the cancer burden in Asia. This study aims to evaluate the burden of gastrointestinal tumors in Asia from 1990 to 2021 using data from the Global Burden of Disease Study 2021 (GBD 2021).

Methods: The absolute incidence, mortality, and disability adjusted life years (DALYs) number and rate of six gastrointestinal tumors(colon and rectum cancer (CRC), stomach cancer (SC), pancreatic cancer (PC), esophageal cancer (EC), liver cancer (LC) and gallbladder and biliary tract cancer (GBTC)) in 48 Asian countries were extracted from GBD 2021. Differences were analyzed based on gender, age, year, location and socio-demographic index (SDI).

Results: In 2021, SC accounted for the highest disease burden in Asia (DALYs=16.41million [95% UI: 13.70, 19.62]). From 1990 to 2021, the age-standardized incidence rates of EC, LC, and SC in Asia declined, while the incidence rates of CRC and PC increased significantly, with CRC showing the largest rise (AAPC=1.08 [95% CI: 1.02 to 1.12]). Gastrointestinal tumors DALY rates peaked at age 70 and above, with males generally exhibiting higher rates than females. Furthermore, East Asia bears a higher burden compared to other Asian subregions. A higher SDI correlates with increased DALY rates for PC, but no linear relationship was observed for other gastrointestinal tumors.

Conclusion: The burden of gastrointestinal tumors in Asia remains high and may continue to increase. Therefore, effective prevention and treatment measures are essential to address the challenge posed by gastrointestinal tumors.

Keywords: Asia; burden; gastrointestinal tumors; trends.

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Conflict of interest statement

The authors declare that there is no conflict of interest in this work.

Figures

Figure 1
Figure 1
The burden of gastrointestinal tumors in four continents, 2021. (A) Incidence; (B) Age-standardized incidence rates(per 100,000); (C) Deaths; (D) Age-standardized deaths rates(per 100,000); (E) DALYs; (F) Age-standardized DALY rates(per 100,000).
Figure 2
Figure 2
Asian temporal trends in the burden of gastrointestinal tumors, 1990–2021. (A) Incidence number (B) Age-standardized incidence rate (C) Deaths number (D) Age-standardized deaths rate (E) DALYs number (F) Age-standardized DALYs rate.
Figure 3
Figure 3
Asian age-standardized DALY rate(per 100,000) of male and female by gastrointestinal tumors in 2021.
Figure 4
Figure 4
Ranking of age-standardized DALY rates(per 100,000) for all gastrointestinal tumors by Asian countries, 2021.
Figure 5
Figure 5
Percentage contribution of DALYs burden to gastrointestinal tumors in Asia, 2021. (A) Different sub-regions; (B) Different SDI levels.
See this image and copyright information in PMC

References

    1. Arnold M, Abnet CC, Neale RE, et al. Global burden of 5 major types of gastrointestinal cancer. Gastroenterology. 2020;159(1):335–349.e15. doi: 10.1053/j.gastro.2020.02.068 - DOI - PMC - PubMed
    1. Kocarnik JM, Compton K, Dean FE, et al. Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the global burden of disease study 2019. JAMA. 8(3):420–444. doi: 10.1001/jamaoncol.2021.6987 - DOI - PMC - PubMed
    1. Temporal patterns of cancer burden in Asia, 1990-2019: a systematic examination for the Global burden of disease 2019 study. Lancet Reg Health Southeast Asia. 2024;21:100333. doi: 10.1016/j.lansea.2023.100333 - DOI - PMC - PubMed
    1. Ferlay J, Colombet M, Soerjomataram I, et al. Cancer statistics for the year 2020: an overview. Int J Canc. 2021. doi: 10.1002/ijc.33588 - DOI - PubMed
    1. Ko KP, Shin A, Cho S, Park SK, Yoo KY. Environmental contributions to gastrointestinal and liver cancer in the Asia-Pacific region. J Gastroenterol Hepatol. 2018;33(1):111–120. doi: 10.1111/jgh.14005 - DOI - PubMed

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