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Review
. 2024 Aug 15;10(16):e36402.
doi: 10.1016/j.heliyon.2024.e36402. eCollection 2024 Aug 30.

Sex-dimorphic functions of orexin in neuropsychiatric disorders

Jinghan Zhang  1 , Kangyu Jin  1   2 , Bing Chen  1   2 , Shangping Cheng  1   2 , Jinfan Jin  3 , Xiaolan Yang  3 , Jing Lu  1   2 , Qinghai Song  3
Affiliations
Review

Sex-dimorphic functions of orexin in neuropsychiatric disorders

Jinghan Zhang et al. Heliyon. .

Abstract

The orexin system regulates a variety of physiological functions, including the sleep-wake cycle, addiction, foraging behavior, stress and cognitive functioning. Orexin levels in central and peripheral are related to the pathogenesis of many diseases, most notably the narcolepsy, eating disorders, stress-related psychiatric disorders, and neurodegenerative diseases. Recently, it has been reported that the orexin system is distinctly sexually dimorphic, and is strongly associated with neuropsychiatric disorders. In this review, we analyzed advancements in the sex differences in the orexin system and their connection to psychoneurological conditions. Considering the scarcity of research in this domain, more research is imperative to reveal the underlying mechanisms.

Keywords: Orexin; Psychoneurological disorders; Sexual dimorphism.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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