Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;94(12):2150-2158.
doi: 10.1111/ans.19231. Epub 2024 Sep 10.

Outcomes following extended resection of radiation-induced angiosarcoma of the breast: a sarcoma unit experience and systematic review

Eyal Mor  1 , Benjamin Baker  1 , Michael A Henderson  1 , Smaro Lazarakis  1 , Catherine Mitchell  1 , David Speakman  1 , Richard Zinn  1 , Angela Webb  1 , Hayden Snow  1 , David E Gyorki  1
Affiliations

Outcomes following extended resection of radiation-induced angiosarcoma of the breast: a sarcoma unit experience and systematic review

Eyal Mor et al. ANZ J Surg. 2024 Dec.

Abstract

Purpose: Radiation-induced angiosarcoma (RIAS) of the breast is a rare tumour with high rate of local recurrence. The aim of this study is to evaluate the outcome of radical resections.

Methods: A retrospective analysis of all patients who underwent extended surgical resection for RIAS of the breast between 2013 and 2022. Included were patients who underwent radical resection, including complete resection of previously irradiated skin and underlying fascia of pectoralis major. Post-operative and long-term oncological outcomes were than analysed. A systematic review was performed using the MEDLINE database in the last 20 years.

Results: Twenty-two (n = 22) patients met the inclusion criteria. The median length of the specimen was 220 mm (range, 120-377 mm). At a median follow-up of 33.5 months (range, 7.9-102.4), 3 (13.6%) patients had both local and metastatic lung disease and 1 (4%) patient with only lung metastasis. The estimated 3- and 5-year OS was 81.1% and 57.9%, respectively. The estimated 3- and 5-year DSS was 91.7% and 65.5%, respectively. The estimated 3- and 5-year DFS rate were both 75.2%. The systematic review identified 17 studies with a recurrence rate ranging from 33% to 100%.

Conclusions: Treatment of RIAS of the breast with an up-front locally extended approach is associated with a low rate of local recurrence compared with the reported literature.

Keywords: angiosarcoma; breast; radiotherapy; sarcoma; surgery.

PubMed Disclaimer

References

    1. Mark RJ, Poen J, Tran LM, Fu YS, Heaps J, Parker RG. Postirradiation sarcoma of the gynecologic tract: a report of 13 cases and a discussion of the risk of radiation‐induced gynecologic malignancies. Am. J. Clin. Oncol. 1996; 19: 59–64.
    1. Sheth GR, Cranmer LD, Smith BD, Grasso‐LeBeau L, Lang JE. Radiation‐induced sarcoma of the breast: a systematic review. Oncologist 2012; 17: 405–418.
    1. Sato F, Yamamoto T. Breast angiosarcoma after primary breast cancer surgery: a systematic review. J Plast Reconstruct Aesthet Surg 2022; 75: 2882–2889.
    1. Nascimento AF, Raut CP, Fletcher CDM. Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol 2008; 32: 1896–1904 Available from URL: https://pubmed.ncbi.nlm.nih.gov/18813119/.
    1. Reijers SJM, Huis in ‘t Veld EA, Grünhagen DJ et al. Prognosis of patients with cutaneous angiosarcoma after surgical resection with curative intent: is there a difference between the subtypes? Ann Surg Oncol 2023; 30: 493–502.

Publication types

Supplementary concepts

LinkOut - more resources