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. 2024 Nov;170(2):277-287.
doi: 10.1007/s11060-024-04736-w. Epub 2024 Sep 10.

Clinical and methylomic features of spinal meningiomas

Khizar R Nandoliya #  1 , Harrshavasan Congivaram #  1 , Mark W Youngblood  1 , William C Chen  2 , Rahul K Chaliparambil  1 , Craig M Horbinski  3 , Abrar Choudhury  2 , Daniel J Brat  3 , James P Chandler  1 , Stephen T Magill  1 , Jean-Paul Wolinsky  4
Affiliations

Clinical and methylomic features of spinal meningiomas

Khizar R Nandoliya et al. J Neurooncol. 2024 Nov.

Abstract

Purpose: The objective of our study was to analyze methylomic and clinical features of a cohort of spinal meningiomas (SMs) resected at our institution.

Methods: This is a retrospective study of patients undergoing SM resection at our institution between 2010 and 2023. Clinical and radiographic characteristics were reviewed and analyzed with standard statistical methods. A Partitioning Around Medoids approach was used to cluster SMs with methylation data in a combined cohort from our institution and a publicly available dataset by methylation profiles. Clinical variables and pathway analyses were compared for the resulting clusters.

Results: Sixty-five SMs were resected in 53 patients with median radiographic follow-up of 34 months. Forty-six (87%) patients were female. The median age at surgery was 65 years and median tumor diameter was 1.9 cm. The five-year progression-free survival rate was 90%, with subtotal resection being associated with recurrence or progression (p = .017). SMs clustered into hypermethylation, intermediate methylation, and hypomethylation subgroups. Tumors in the hypermethylated subgroup were associated with higher WHO grade (p = .046) and higher risk histological subtypes (p <.001), while tumors in the hypomethylated subgroup were least likely to present with copy-number loss in chromosome 22q (p <.0001). SMs classified as immune-enriched under a previously developed intracranial meningioma classifier did not have increased leukocyte fractions or hypomethylation of genes typically hypomethylated in immune-enriched tumors.

Conclusion: SMs are more benign than their intracranial counterparts, and gross-total resection results in long term PFS. Methylation profiling identifies subgroups with differences in clinical variables.

Keywords: DNA methylation; Methylation profiling; Outcomes; Spinal meningioma.

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References

    1. Ostrom QT, Price M, Neff C et al (2023) CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2016–2020. Neurooncology 25(Supplement4):iv1–iv99. https://doi.org/10.1093/neuonc/noad149 - DOI
    1. Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the Central Nervous System: a summary. Neuro Oncol Aug 2(8):1231–1251. https://doi.org/10.1093/neuonc/noab106 - DOI
    1. Choudhury A, Magill ST, Eaton CD et al (2022) Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet May 54(5):649–659. https://doi.org/10.1038/s41588-022-01061-8 - DOI
    1. Choudhury A, Chen WC, Lucas CG et al (2023) Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features. Neuro Oncol Mar 14(3):520–530. https://doi.org/10.1093/neuonc/noac224 - DOI
    1. Youngblood MW, Miyagishima DF, Jin L et al (2021) Associations of meningioma molecular subgroup and tumor recurrence. Neuro Oncol May 5(5):783–794. https://doi.org/10.1093/neuonc/noaa226 - DOI

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