Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Sep 10;8(17):4711-4713.
doi: 10.1182/bloodadvances.2024013476.

Myo1c drives actin-dependent VWF expulsion from EC WPBs

Affiliations
Comment

Myo1c drives actin-dependent VWF expulsion from EC WPBs

Luiza Rusu et al. Blood Adv. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Schematic representation of working model of Myo1c-mediated membrane actin nucleation required for EC WPB exocytosis.

Comment on

References

    1. El-Mansi S, Mitchell TP, Mobyen G, et al. Myosin-1C augments secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane. Blood Adv. 2024;8(17):4714–4726. - PubMed
    1. El-Mansi S, Robinson CL, Kostelnik KB, et al. Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor. Blood. 2023;141(8):930–944. - PMC - PubMed
    1. Nguyen TTN, Koerdt SN, Gerke V. Plasma membrane phosphatidylinositol (4,5)-bisphosphate promotes Weibel-Palade body exocytosis. Life Sci Alliance. 2020;3(11) - PMC - PubMed
    1. Gowrisankaran S, Houy S, Del Castillo JGP, et al. Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin. Nat Commun. 2020;11(1):1266. - PMC - PubMed
    1. El-Mansi S, Nightingale TD. Emerging mechanisms to modulate VWF release from endothelial cells. Int J Biochem Cell Biol. 2021;131 - PubMed