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. 2024 Oct;34(10):805-808.
doi: 10.1016/j.tcb.2024.08.003. Epub 2024 Sep 9.

Telomere dynamics as mediators of gut microbiota-host interactions

Michael L Pepke  1 , Søren B Hansen  2 , Morten T Limborg  2
Affiliations

Telomere dynamics as mediators of gut microbiota-host interactions

Michael L Pepke et al. Trends Cell Biol. 2024 Oct.

Abstract

The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.

Keywords: gut barrier; holobiont; microbiome; senescence; telomerase; telomere length.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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