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. 2024 Sep 1;16(1):e2024071.
doi: 10.4084/MJHID.2024.071. eCollection 2024.

Anorectal Pathologies in the Course of Acute Leukaemias; Predictive Parameters

Fatma Yilmaz  1 , Bugra Saglam  2 , Ufuk Gorduk  1 , Ugur Kalan  1 , Hacer Berna Afacan Ozturk  1 , Ahmet Kursad Gunes  1 , Murat Albayrak  1
Affiliations

Anorectal Pathologies in the Course of Acute Leukaemias; Predictive Parameters

Fatma Yilmaz et al. Mediterr J Hematol Infect Dis. .

Abstract

Introduction: Patients with leukaemia are exposed to infections as long as they are neutropenic. During this period, anorectal pathologies are among the common foci of infection with high mortality. In this study, we aim to investigate the factors that may have a predictive effect on early diagnosis and rapid intervention in perianal complications occurring in neutropenic patients diagnosed with leukaemia.

Materials and methods: A total of 90 patients with acute leukaemia, including 45 patients with anorectal pathology and 45 patients without anorectal pathology, were analysed. Demographics, blood group, BMI, haemogram and biochemical parameters at the time of diagnosis, and types of perianal pathology were recorded.

Results: In the group of patients with anorectal pathology, WBC, lymphocytes, monocytes, and LDH were significantly (p<0.05) higher, and platelets, MPV, and PCT were significantly (p<0.05) lower. The multivariate model showed significant-independent (p<0.05) efficacy of WBC and MPV values in differentiating patients with and without anorectal pathology. A significant efficacy was observed at the WBC cut-off of 17000 [area under the curve 0.656 (0.542-0.770)] and the MPV cut-off of 10 [area under the curve 0.667 (0.554-0.780)] in differentiating patients with and without anorectal pathology.

Discussion: Anorectal pathologies are common foci of infection in patients with acute leukaemia. Having predictive parameters that may help for early intervention will help the clinician. This is the first study in the literature to compare a control group with a group with anorectal pathologies in leukaemia patients providing a cut-off for WBC.

Keywords: Acute Leukemia; Leukocyte count; MPV; Perianal pathologies.

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Conflict of interest statement

Competing interests: The authors declare no conflict of Interest.

Figures

Figure 1
Figure 1
White Blood Cell.
Figure 2
Figure 2
Figure 3 and 4
Figure 3 and 4
WBC and MPV values.
See this image and copyright information in PMC

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